With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20196-21-8,Thiomorpholin-3-one,as a common compound, the synthetic route is as follows.
Step B Thiomorpholin-3-thione A mixture of 1.17 g (10 mmol) of thiomorpholin-3-one and 11 mmoles of Lawesson’s reagent in 25 mL of toluene was heated to reflux 2 hrs. The reaction mixture was cooled and the solvent was removed to give a residue. This was taken up in methylene chloride and applied on silica gel column and eluted with ethyl acetate containing methylene chloride (10%). The desired thiomorpholin-3-thione in 65% yield as a solid. 1 H NMR (CDCl3): 2.90(m,2H); 3.62(m,2H); 3.76(s,2H); 8.65(b,1H)
As the paragraph descriping shows that 20196-21-8 is playing an increasingly important role.
Reference£º
Patent; Merck & Co., Inc.; US5629322; (1997); A;,
Thiomorpholine – Wikipedia
Thiomorpholine | C4H9NS – PubChem