76176-87-9, Thiomorpholine-1-oxide hydrochloride is a Thiomorpholine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Inermediate AU: (c/s)-5-lodo-7-[3-(1 -oxo-thiomorpholin-4-ylmethyl)-cyclobutyl]-7H- pyrrolo[2,3-d]pyrimidin-4-ylamineTo the stirred solution of (c/s)-[3-(4-amino-5-iodo-pyrrolo [2,3-d]pyrimidin-7-yl)-cyclobutyl] methanol (Intermediate J: 348 mg, 1.0 mmol) and acetonitrile (70 mL) was added IBX (Atlantic SciTech 86900: 561 mg, 2.0 mmol, 2 eq). The reaction mixture was stirred for 1 hour at 80 C. The reaction mixture was filtered at 40 C and the filtrate was concentrated. To the residue was added subsequently DCM (50 mL), ethyl-diisopropyl-amine (3.43 mL, 20 mmol, 20 eq), 1 -oxide thiomorpholin hydrochloride (312 mg, 2.0 mmol, 2 eq) and sodium triacetox- yborohydride (637 mg, 3.0 mmol, 3 eq) with stirring at room temperature. The reaction mixture was stirred for 1 hour at ro temperature and then partitioned between NaHC03 1 M and EtOAc. The combined organic layers were washed with water and brine, dried (Na2S04), filtered and concentrated. The residue was purified by silica gel column chromatography (DCM/MeOH/NH3aq, 200:20: 1 ) to afford the title compound as pale yellow crystals: HPLC/MS (Method Z) tR 0.92 minutes, M+H 446.2. TLC; Rf = 0.26 (DCM/MeOH/NH3aq, 200:20:1).
The synthetic route of 76176-87-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NOVARTIS AG; IRM LLC, a Delaware Limited Liability Company; CHEN, Bei; FAIRHURST, Robin, Alec; FLOERSHEIMER, Andreas; FURET, Pascal; JIANG, Songchun; LU, Wenshuo; MARSILJE, Thomas, H.; VAUPEL, Andrea; WO2011/64211; (2011); A1;,
Thiomorpholine – Wikipedia
Thiomorpholine | C4H9NS – PubChem