As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO287,mainly used in chemical industry, its synthesis route is as follows.,59801-62-6
To a solution of 7-(3-chloro-phenylamino )-3-methyl-lH-pyrrolo[2,3-c ]pyridine-4-carboxylic acid (150mg) in dimethylformamide (4ml) was added 4-ethylmorpholine (253mul), thiomorpholine 1,1- dioxide hydrochloride (90. mg), 1-hydroxybenzotriazole hydrate (105mg) and 1-(3- dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride (115mg) and the solution stirred at room temperature overnight. The dimethylformamide was evaporated and the residue dissolved in ethyl acetate (40ml) and washed with 5% sodium hydrogen carbonate solution (25ml) and water (25ml). The organic layer was dried (MgS04) and evaporated to give an orange oil. The residue was triturated with diethyl ether to give a white solid which was then filtered off, sucked dry then dried at 40C under vacuum to afford the title compound (75mg). NMR (d6-DMSO) 8 2.11 (3H, s), 2.49-2.57 (8H, m), 6.94 (1H, d), 7.31 (1H, t), 7.38 (1H, s), 7.73 (1H, d), 7.82 (1H, s), 8.32 (1H, s), 9.45 (1H, s), 11.65 (1H, brs). LC/MS [MH+] 419 consistent with molecular formula C19H1935ClN4O3S
With the synthetic route has been constantly updated, we look forward to future research findings about Thiomorpholine 1,1-dioxide hydrochloride,belong Thiomorpholine compound
Reference£º
Patent; GLAXO GROUP LIMITED; WO2005/121140; (2005); A1;,
Thiomorpholine – Wikipedia
Thiomorpholine | C4H9NS – PubChem