Name is (R)-4-(tert-Butoxycarbonyl)thiomorpholine-3-carboxylic acid, as a common heterocyclic compound, it belongs to Thiomorpholine compound, and cas is 114525-81-4, its synthesis route is as follows.
To a solution of Intermediate 3 (0.2g, 0.419 mmol) in DMF (5 mL), were added (R)-4- (teri-butoxycarbonyl)thiomorpholine-3-carboxylic acid (0.104 g, 0.419 mmol) and 2-(3H- [1 ,2,3]triazolo[4,5-b]pyridin-3-yl)-l , 1 ,3,3-tetramethylisouronium hexafluorophosphate(V) (0.191 g, 0.503 mmol) at an ambient temperature. After stirring for 12 h, the reaction was extracted with ethyl acetate. The organic extract was dried over MgSO4 and concentrated under reduced pressure to give Compound 454 and was treated with 4.0 M HQ in dioxane (5mL). After 5 h, the reaction was concentrated under reduced pressure, neutralized with 2.0 M NaOH and then extracted with ethyl acetate. The organic layer was dried over MgS04 and concentrated under reduced pressure to give the crude title compound, which was used for the next step without further purification (0.169 g, 66.9 ). LCMS m/z = 606.50.10 [M+H]+.
114525-81-4, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,114525-81-4 ,(R)-4-(tert-Butoxycarbonyl)thiomorpholine-3-carboxylic acid, other downstream synthetic routes, hurry up and to see
Reference£º
Patent; ARENA PHARMACEUTICALS, INC.; TRAN, Thuy-Anh; BLACKBURN, Anthony C.; KRAMER, Bryan A.; NAGURA, Maiko; SAGE, Carleton R.; SHIN, Young-Jun; ZOU, Ning; WO2013/70657; (2013); A1;,
Thiomorpholine – Wikipedia
Thiomorpholine | C4H9NS – PubChem