39093-93-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Thiomorpholine 1,1-dioxide, cas is 39093-93-1,the Thiomorpholine compound, it is a common compound, a new synthetic route is introduced below.
Step 1: preparation of compound 15-2: To a solution of compound 15-1 (541 mg, 4.0 mmol) and Et3N (1.21 g, 12.0 mmol) in THF (20.0 mL), a solution of triphosgene (1.42 g, 4.8 mmol) in THF (5.0 mL) was added dropwise. After the mixture was stirred at rt o.n., water was added and it was extracted with EtOAc. The organic layer was combined and washed with brine, dried over Na2S04, filtered. Solvent was removed and the residue was purified by column chromatography to give a white solid (760 mg, yield: 96percent). HNMR (400 MHz, DMSO- 6) ^ 4.23 (m, 2H), 4.08-4.14 (m, 2H), 3.39-3.48 (m, 1H), 3.13-3.15 (m, 4H), 1.18-1.27 (m, 2H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Thiomorpholine 1,1-dioxide, 39093-93-1
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC; CHEN, Huifen; CRAWFORD, Terry; MAGNUSON, Steven, R.; NDUBAKU, Chudi; WANG, Lan; WO2013/113669; (2013); A1;,
Thiomorpholine – Wikipedia
Thiomorpholine | C4H9NS – PubChem