39093-93-1, A common heterocyclic compound, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route., 39093-93-1
The above acteyl chloride (1.122 g; 3.27 mmol) was dissolved in 10 mL DMF. Thiomorpholine 1,1-dioxide (0.442 g; 3.27 mmol) was added followed by DIPEA (0.63 mL; 3.6 mol) and DMAP (16 mg; 0.131 mmol). The reaction mixture was heated in a 60¡ã C. oil bath overnight. Water was added to the reaction mixture, and it was extracted with EtOAc three times. The organics were combined and washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated. The yellow residue obtained was purified by flash column chromatography on silica gel using 2.5percent methanol in DCM mixture as eluent then switched to 5percent methanol in DCM. The title compound was obtained in >95percent purity (HPLC) as a white foam (781 mg; 54percent yield).
According to the analysis of related databases, 39093-93-1, the application of this compound in the production field has become more and more popular.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2010/9964; (2010); A1;,
Thiomorpholine – Wikipedia
Thiomorpholine | C4H9NS – PubChem