As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 39093-93-1, name is Thiomorpholine 1,1-dioxide. This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 39093-93-1
1,3-dibromobenzene (1.6g, 6.81mmol),thiomorpholine dioxide (300mg, 2.22mmol) BINAP (300mg, 0.48mmol), cesium carbonate (2.5g, 23.67mmol) and palladiumacetate (150mg) were dissolved in 10mL dry toluene in a 50mL single-neck flask. The reaction solution washeated to 90¡ãC under argon atmosphere and stirred for 18 hours. After completion of the reaction, the reaction solutionwas filtered, the filtrate was evaporated to dryness under reduced pressure, and the residue was purified by columnchromatography to give 90mg product, which was directly used in the next step.
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Reference£º
Patent; Shanghai Pharmaceuticals Holding Co., Ltd.; XIA, Guangxin; LI, Di; ZUO, Hongjian; WU, Guangsheng; DUAN, Lingjun; ZHANG, Jing; MAO, Yu; LIU, Yanjun; (152 pag.)EP3424928; (2019); A1;,
Thiomorpholine – Wikipedia
Thiomorpholine | C4H9NS – PubChem