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Anilinoquinazoline inhibitors of the RET kinase domain – Elaboration of the 7-position
We have previously reported a series of anilinoquinazoline derivatives as potent and selective biochemical inhibitors of the RET kinase domain. However, these derivatives displayed diminished cellular potency. Herein we describe further optimisation of the series through modification of their physicochemical properties, delivering improvements in cell potency. However, whilst cellular selectivity against key targets could be maintained, combining cell potency and acceptable pharmacokinetics proved challenging.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 39093-93-1. In my other articles, you can also check out more blogs about 39093-93-1
Reference£º
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem