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PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATING OR PREVENTING A RESPIRATORY SYNCYTIAL VIRUS INFECTION

Pyrimidine derivatives of formula (I) wherein: Z is a direct bond or -(CH2)n- wherein n is 1 or 2; one of X and Y is N, CH or CF, and the other of X and Y is CH; one of R1 and R2 is selected from -NHR, -NR2, -OR, -SR, -S(O)R, -S(O)2R and a group of the following formula (A) and the other of R1 and R2 is selected from -NHR’, -OH, -OR’ and a group of the above formula (A); R is unsubstituted C1-C6 alkyl; R’ is a group selected from C1-C6 alkyl, 5- to 12-membered aryl and C3-C6 cycloalkyl, which group is unsubstituted or substituted; W is -(CH2)m-, -CH2-O-CH2-, -CH2-S-CH2- or -CH2-S(O)2-CH2-; p is 1, q is an integer of 1 – 6 and V is N; or p is 1, q is 0 and V is CH; or p is 0, q is 0 and V is N; r is 0 or 1; and R3 is -(CH2)s-NH2 or -(CH2)s-OH wherein s is 0 or an integer of 1 to 4; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.

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Theoretical and experimental studies of cycloconjugation involving second-row elements

In a method proposed to investigate conjugative interactions between second-row elements (S, P) amd a pi-electron system, barriers to amide rotation have been measured using NMR line-shape methods, for N-acetyl-4-X(hetero)-1,4-dihydropyridines (X = SO2,7; P(O)OCH3,13; C(CH3)2, 6 (reference)) as well as the dihydro (8a) and tetrahydro (9) derivatives, respectively, of 7. It is suggested that such interactions would stabilize the transition states for amide rotation by cycloconjugation but not the planar equilibrium states, compressing the barriers relative to reference 6. In fact, amide barriers in 7,13, and N-acetylpyrrole are substantially (>6 kcal) less than in 6, 8ab, and 9, all ca. 17 kcal, in all of which saturated centers interrupt possible cycloconjugation. These conclusions are supported by the results of ab initio calculations at the Hartree-Fock level with the 3-21G(*) basis set.

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JAK kinase inhibitors and uses thereof (by machine translation)

The invention discloses a having the following general formula (I) compound. The invention also disclosed comprising this compound JAK kinase inhibitor and the compounds in the preparation of the treatment in the JAK related diseases of the application. JAK kinase inhibitors of the present invention, can inhibit the signal transduction of the involved in various JAK1, JAK2, JAK3 and TYK2 kinase biological activity, can effectively clinical treatment of various inflammatory diseases and JAK-mediated signal transduction by the driving of various diseases, very broad application prospects. . (by machine translation)

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FUSED TRICYCLIC COMPOUNDS AS NOVEL mTOR INHIBITORS

The present invention provides Fused Tricyclic Compounds of the Formula (1) wherein Q, R1, R2, R3, and R4 are as defined herein, and pharmaceutically acceptable salts of such Fused Tricyclic Compounds. The Fused Tricyclic Compounds are useful in the treatment of cancer and other proliferative disorders

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6,7-Dimethoxy-2-(4-thiomorpholinyl)-4-quinazolinamine and related sulfoxide and sulfone

Disclosed are a series of quinazoline derivatives which have activity as hypotensive agents.

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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Product Details of 39093-93-1, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 39093-93-1, name is Thiomorpholine 1,1-dioxide. In an article£¬Which mentioned a new discovery about 39093-93-1

[1, 2, 4] Triazolo [1, 5 – a] pyridine compound and its preparation method and medical use (by machine translation)

The present invention relates to [1, 2, 4] triazolo [1, 5 – a] pyridine compound and its preparation method and medical use. In particular, the invention relates to compounds of the general formula I shown, its preparation method and containing pharmaceutical compositions of the compounds, and their use as JAK kinase inhibitors, the compound and its containing pharmaceutical compositions of the compounds can be used for treating diseases associated with JAK kinase activity, such as inflammation, autoimmune disorders, such as cancer. Wherein the general formula I in the definition of each substituent as defined in the specification. (by machine translation)

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COMPOUNDS AND METHOD OF USE

This present disclosure relates to compounds with ferroptosis inducing activity, a method of treating a subject with cancer with the compounds, and combination treatments with a second therapeutic agent.

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HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS

The present invention is directed to heterocyclic compounds which are antagonists of CGRP receptors and may be useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

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1,1-DIOXO-THIOMORPHOLINYL INDOLYL METHANONE DERIVATIVES

The present invention relates to compounds of formula I wherein R1, R2 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.

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39093-93-1, Name is Thiomorpholine 1,1-dioxide, belongs to Thiomorpholine compound, is a common compound. SDS of cas: 39093-93-1In an article, once mentioned the new application about 39093-93-1.

SOLID FORMS OF 1,L-DIOXO-4-THIOMORPHOLINYL)-[6-[[3(4-FLUOROPHENYL)-5-METHYL-4-ISOXAZOLYL]METHOXY]-3-PYRIDINYL]-METHANONE

The instant invention relates to novel solid forms of the compound of formula (I), as well as solvates, inclusion complexes with other suitable compounds, processes for their manufacture, pharmaceutical compositions containing these solid forms, and their use as medicaments.

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