Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter. category: Thiomorpholine, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 39093-93-1
4- (4-(HETEROCYCLYLALKOXY}PHENYL)-1-(HETEROCYCLYL-CARBONYL)PIPERIDINE DERIVATIVES AND RELATED COMPOUNDS AS HISTAMINE H3 ANTAGONISTS FOR THE TREATMENT OF NEUROLOGICAL DISEASES SUCH AS ALZHEIMER’S
The present invention provides, in a first aspect, a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein: R1 represents-C1-6 alkyl-O-C1-6 alkyl,-C3-8 cycloalkyl, aryl, heterocyclyl, heteroaryl and other groups; X represents a bond, O, CO, OCH2, CH2 O or SO2; Z represents CO, CONR10 or SO2; R10 represents hydrogen, C1-6 alkyl,-C3-8 cycloalkyl, aryl, heterocyclyl, heteroaryl; A represents a single or a double bond; m and n independently represent 0, 1 or 2; R2 represents hydrogen, C1-6 alkyl or C1-6 alkoxy; R3 represents halogen, C1-6 alkyl, hydroxy, C1-6 alkoxy, cyano, amino,-COC1-6 alkyl,-SO2C1-6 alkyl or trifluoromethyl; R4 represents-(CH2)q-NR11R12 or a group of formula (i) wherein all the other substituents are as defined in claim 1. Compounds of formula (I) and their pharmaceutically acceptable salts have affinity for and are antagonists and/or inverse agonists of the histamine H3 receptor and are believed to be of potential use in the treatment of neurological diseases including Alzheimer’s disease.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, category: Thiomorpholine, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about category: Thiomorpholine
Reference£º
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem