Application of 81-64-1, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 81-64-1, Name is 1,4-Dihydroxyanthracene-9,10-dione, SMILES is O=C1C2=C(C=CC=C2)C(C3=C(O)C=CC(O)=C13)=O, belongs to thiomorpholine compound. In a article, author is Mohamed, Tarek, introduce new discover of the category.
Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors
A group of 2,4-disubstituted pyrimidine derivatives (7a-e, 8a-e and 9a-d) that possess a variety of C-2 aliphatic five-and six-membered heterocycloalkyl ring in conjunction with a C-4 arylalkylamino substituent were designed, synthesized and evaluated as cholinesterase (ChE) inhibitors. The steric and electronic properties at C-2 and C-4 positions of the pyrimidine ring were varied to investigate their effect on ChE inhibitory potency and selectivity. The structure-activity relationship (SAR) studies identified N-benzyl-2-thiomorpholinopyrimidin-4-amine (7c) as the most potent cholinesterase inhibitor (ChEI) with an IC50 = 0.33 mu M (acetylcholinesterase, AChE) and 2.30 mu M (butyrylcholinesterase, BuChE). The molecular modeling studies indicate that within the AChE active site, the C-2 thiomorpholine substituent was oriented toward the cationic active site region (Trp84 and Phe330) whereas within the BuChE active site, it was oriented toward a hydrophobic region closer to the active site gorge entrance (Ala277). Accordingly, steric and electronic properties at the C-2 position of the pyrimidine ring play a critical role in ChE inhibition. (C) 2010 Elsevier Ltd. All rights reserved.
Application of 81-64-1, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 81-64-1.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem