Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 99-10-5, Name is 3,5-Dihydroxybenzoic acid, molecular formula is C7H6O4. In an article, author is Ayers, Sloan,once mentioned of 99-10-5, Formula: 154.1201.
Amine over-alkylation side products in the synthesis of BMS-955176
Over-alkylation side products are common in the alkylation of amines by substitution. In the synthesis of the novel HIV Maturation inhibitor BMS-955176, two over-alkylation byproducts were routinely observed at the penultimate synthetic step, in which a thiomorpholine dioxide side chain was added to the core molecule by alkylation of a primary amine. These two byproducts had drastically different HPLC relative retention times, despite both containing only one additional side chain. Adding complexity to the challenge of solving their structures was the proclivity of the two byproducts to interconvert. Positive- and negative-ion HRMS, as well as isolation and 1D and 2D NMR were utilized to determine their structures. These byproducts were additionally problematic in that they led to daughter impurities at the API step. (C) 2018 Elsevier Ltd. All rights reserved.
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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem