Day: March 19, 2021

Application of 120-07-0, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 120-07-0, Name is 2,2-(Phenylimino)diethanol, SMILES is OCCN(C1=CC=CC=C1)CCO, belongs to thiomorpholine compound. In a article, author is Xu Jian, introduce new discover of the category.

Synthesis and Anti-tumor Activities of Novel Artemisone-piperazine-sulfonamide Derivatives

A series of artemisone derivatives was prepared from dihydroartemisinin through a seven-step conversion, which included the amination of dihydroartemisinin with thiomorpholine, the oxidation of thiomorpholine (2) with hydrogen peroxide, the alkylation of sulfone (3) with the silyl protected 4-iodobutan-1-ol, the desilylation of artemisone derivative(4), the conversion of alcohol(5) to iodide(6), the amination of iodide (6) with piperazine, and the sulfonylation of compound 7 with a wide arrange of sulfonyl chlorides to the desired artemisone derivatives (8). All the new compounds were identified by NMR spectra, IR and HRMS technology. The anti-tumor activities of artemisone derivatives against human hepatoma SMMC-7721 cell lines were evaluated by 3-(4, 5 -dimethylthiazol-2-yl)-2, 5 -diphenyltetrazolium bromide (MTT) method. It was found that these new artemisone-piperazine-sulfonamide derivatives could inhibit the proliferation of the liver cancer cell by inducing apoptosis, and the lowest IC50 value of the treatment for 72 h was 0. 09 mu mol/mL.

Application of 120-07-0, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 120-07-0.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Diao, Peng-Cheng, once mentioned the application of 2835-98-5, Name is 2-Amino-5-methylphenol, molecular formula is C7H9NO, molecular weight is 123.15, MDL number is MFCD00007693, category is thiomorpholine. Now introduce a scientific discovery about this category, Product Details of 2835-98-5.

Synthesis and biological evaluation of novel indole-pyrimidine hybrids bearing morpholine and thiomorpholine moieties

Based on our previous screening hit compound 1, a series of novel indole-pyrimidine hybrids possessing morpholine or thiomorpholine moiety were synthesized via an efficient one-pot multistep synthetic method. The antiproliferative activities of the synthesized compounds were evaluated in vitro against four cancer cell lines including HeLa, MDA-MB-231, MCF-7, and HCT116. The results revealed that most compounds possessed moderate to excellent potency. The IC50 values of the most promising compound 15 are 0.29, 4.04, and 9.48 mu M against MCF-7, HeLa, and HCI116 cell lines, respectively, which are 48.0, 4.9, and 1.8 folds more active than the lead compound 1. Moreover, fluorescence-activated cell sorting analysis revealed that compound 14 showing the highest activity against HeLa (IC50 = 2.51 mu M) displayed a significant effect on G(2)/M cell-cycle arrest in a concentration-dependent manner in HeLa cell line. In addition, representative nine active hybrids were evaluated for tubulin polymerization inhibitory activities, and compound 15 exhibited the most potent anti-tubulin activity showing 42% inhibition at 10 mu M. These preliminary results encourage a further investigation on indole-pyrimidine hybrids for the development of potent anticancer agents that inhibit tubulin polymerization. (C) 2017 Elsevier Masson SAS. All rights reserved.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Synthetic Route of 492-37-5, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 492-37-5, Name is 2-Phenylpropionic acid, SMILES is C1=C(C(C(O)=O)C)C=CC=C1, belongs to thiomorpholine compound. In a article, author is El-Abadelah, MM, introduce new discover of the category.

Synthesis and properties of some new 5-fluoro-6-(heterocyclyl) benzofuroxans

A series of 5-fluoro-6-(N-heterocyclyl) benzofuroxans (3b-e) have been prepared by hypochlorite oxidative cyclization of the respective 4-fluoro-5-(N-heterocyclyl)-2-nitroanilines (2b-e). The heterocyclyls include piperazine, N-(2-hydroxyerhyl)piperazine, morpholine and thiomorpholine. Some bio-properties and spectral data of these new derivatives are presented.

Synthetic Route of 492-37-5, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 492-37-5.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Application of 123843-67-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 123843-67-4, Name is 4-Bromo-2,6-difluorobenzonitrile, SMILES is N#CC1=C(F)C=C(Br)C=C1F, belongs to thiomorpholine compound. In a article, author is Lima, LM, introduce new discover of the category.

Synthesis and anti-inflammatory activity of phthalimide derivatives, designed as new thalidomide analogues

This paper describes the synthesis and anti-inflammatory activity of new N-phenyl-phthalimide sulfonamides (3a-e) and the isosters N-phenyl-phthalimide amides (4a-e), designed as hybrids of thalidomide (1) and aryl sulfonamide phosphodiesterase inhibitor (2), In these series, compound 3e (LASSBio 468). having a sulfonyl-thiomorpholine moiety, showed potent inhibitory activity on LPS-induced neutrophil recruitment with ED50 = 2.5 mg kg(-1), which was correlated with its inhibitory effect on TNF-alpha level. (C) 2002 Elsevier Science Ltd. All rights reserved.

Application of 123843-67-4, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 123843-67-4 is helpful to your research.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 104-21-2, Name is 4-Methoxybenzyl acetate, formurla is C10H12O3. In a document, author is El-Faham, Ayman, introducing its new discovery. COA of Formula: C10H12O3.

Morpholine-based immonium and halogenoamidinium salts as coupling reagents in peptide synthesis

Here we describe a new family of N-form immonium-type coupling reagents that differ in their carbocation skeleton structure. The N-methylpiperazine derivative failed to form immonium salts, while the thiomorpholine derivative did not give better results than the coupling reagents currently used. The presence of the morpholine had a marked influence on the solubility and stability as well as the reactivity of the reagent. Finally, the fluoroamidinium salt performed extremely well in the presence of only 1 equiv of base, thereby confirming the effect of the proton acceptor in the reaction.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 30379-55-6, Name is 2-(Benzyloxy)acetic acid, molecular formula is C9H10O3. In an article, author is Britton, D,once mentioned of 30379-55-6, Application In Synthesis of 2-(Benzyloxy)acetic acid.

Copper(I) cyanide-thiomorpholine (3/1)

In the polymeric 3/1 complex of copper(I) cyanide and thiomorpholine, 3CuCN . C(4)H(9)NS or [Cu(3)(CN)(3)(C(4)H(9)NS)](n), the CuCN forms two-dimensional sheets, which are held together by the thiomorpholine. Each thiomorpholine molecule bonds to three different sheets.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

1633-22-3, Name is Tricyclo[8,2,2,24,7]hexadeca-4,6,10,12,13,15-hexaene, molecular formula is C16H16, belongs to thiomorpholine compound, is a common compound. In a patnet, author is Fanigliulo, Ameriga, once mentioned the new application about 1633-22-3, Formula: C16H16.

Development and validation of a stability indicating method for S-carboxymethyl-L-cysteine and related degradation products in oral syrup formulation

A stability-indicating method for the determination of S-carboxymethyl-L-cysteine and related degradation impurities in Exputex (R) 250 mg/5 mL syrup was developed in anion-exchange liquid chromatography mode. A forced degradation study supported the method development to ensure stability indicating conditions. Aqueous solutions of the active pharmaceutical ingredient and syrup samples at different pH-values were stress-tested in different thermal, light exposure and headspace conditions. One degradation product was detected in thermal stress studies at 60 degrees C and 80 degrees C in the pH range 5.0-7.0 and was identified by mass spectrometry as 5-oxo-thiomorpholine-3-carboxylic acid (lactam of carbocysteine). A second degradation product was only generated in moderately strong oxidizing conditions (0.5% H2O2 aqueous solution) and was identified as S-carboxymethyl-L-cysteine-(R/S)-sulphoxide (carbocysteine sulphoxide). The method was developed on a Zorbax SAX column, in isocratic mode. The mobile phase consisted of 200 mM phosphate solution at pH 4.0 and acetonitrile (50:50 v/v) and UV detection was performed at a wavelength of 205 nm. The method was linear for carbocysteine (R > 0.9982) over a concentration range of 2.5-50 mu g/mL and 0.4-0.6 mg/mL. Linearity for the impurities was shown from the LOQ to 50 mu g/mL. Specificity was verified and accuracy demonstrated for the active ingredient and its degradation products in syrup samples at 3 levels around their respective specification limits. Repeatability, intermediate precision and inter-laboratory reproducibility were assessed on three commercial batches, analyzed in triplicate by two operators at both the transferring and the receiving site and demonstrated a successful method transfer to the manufacturing quality control laboratory. (C) 2015 Elsevier B.V. All rights reserved.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 657-84-1, Name is Sodium p-toluenesulfonate, SMILES is O=S(C1=CC=C(C)C=C1)([O-])=O.[Na+], in an article , author is Artico, M, once mentioned of 657-84-1, Computed Properties of C7H7NaO3S.

N-[4-(1,1 ‘-biphenyl)methyl]-4-(4-thiomorpholinylmethyl)benzenamines as non-oxazolidinone analogues of antimycobacterial U-100480.

Thiomorpholine analogues of U-100480 with the biphenylmethyl group replacing the acetamidomethyloxazolidinone moiety have been synthesized and tested as antimycobacterial agents together with various related derivatives. Some biphenyl derivatives were endowed with high activity against Mycobacterium tuberculosis and other non-tuberculous mycobacteria. (C) 1998 Elsevier Science Ltd. All rights reserved.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 1965-09-9, Name is 4,4-Oxydiphenol, molecular formula is C12H10O3. In an article, author is Strotman, Neil A.,once mentioned of 1965-09-9, Name: 4,4-Oxydiphenol.

Development of a Safe and High-Throughput Continuous Manufacturing Approach to 4-(2-Hydroxyethyl)thionnorpholine 1,1-Dioxide

Continuous processing enabled the highly energetic double conjugate addition of ethanolamine to divinylsulfone to prepare 2 kg of 4-(2-hydroxyethyl)thiomorpholine 1,1-dioxide, as an intermediate in the synthesis of HIV Maturation Inhibitor BMS-955176. In situ IR was employed to monitor the steady state of the transformation for increased robustness via appearance of the thiomorpholine dioxide moiety and disappearance of the divinylsulfone. Surprisingly, a series of oligomers formed as intermediates, which converted to product with extended aging or heating, consistent with computational predictions. By running this process in flow, the highly exothermic reaction could be safely executed in an equal volume of water as the only solvent, despite an adiabatic temperature rise of 142 degrees C, leading to a streamlined and efficient process.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 88-68-6, Name is 2-Aminobenzamide, SMILES is O=C(N)C1=CC=CC=C1N, in an article , author is Geue, JP, once mentioned of 88-68-6, Formula: C7H8N2O.

The formation of fluorescent alkali metal and alkaline earth complexes by 1-(2-{10-[2-piperazinoethyl]-9-anthryl}ethyl)piperazine and alkaline earth complexes by 4-(2-{10-[2-(1,4-thiazinan-4-yl)ethyl]-9-anthryl}ethyl)thiomorpholine in acetonitrile

The formation of fluorescent alkali metal and alkaline earth complexes of 1-(2-{10-[2-piperazinoethyl]9- anthryl} ethyl) piperazine ( 1) and alkaline earth complexes by 4-(2-{10-[2-(1,4-thiazinan-4-yl) ethyl]-9-anthryl} ethyl) thiomorpholine ( 2) in acetonitrile is reported. Both ( 1) and ( 2) have ‘fluorophore – spacer – receptor’ structures in the sequences ‘anthracene – dimethylene – piperazine’ and ‘anthracene – dimethylene – thiomorpholine’, respectively. Complexation by alkali metal ions and alkaline earth ions, Mm+, modulate photoinduced electron transfer ( PET) to increase the fluorescence of ( 1) and complexation of alkaline earth ions similarly increases the fluorescence of ( 2). The two receptors of ( 1) and ( 2) may either complex Mm+ singly to form [ML](m+) or cooperatively to form a ‘sandwich’ complex [ML’](m+) characterized together by complexation constant K-1 and quantum yield phi(1). They may also complex two Mm+ in [M2L](2m+) characterized by K-2 and phi(2). Typical data are exemplified for (1) and Mm+ = Na+ by K-1 = 1.33 x 10(5) dm(3) mol(-1) (phi(1) = 0.02) and K-2 = 4.20 x 10(2) dm(3) mol(-1) (phi(1) = 0.07), for (1) and Mm+ = Ca2+ by K-1 = 3.2 x 10(6) dm(3) mol(-1) (phi(1) = 0.34) and K-2 = 1.32 x 10(4) dm(3) mol(-1) (phi(2) = 0.54), and for (2) and Mm+ = Ca2+ by K-1 = 2.29 x 10(4) dm(3) mol(-1) (phi(1) = 0.20) and K-2 = 8.0 x 10(2) dm(3) mol(-1) (phi(2) = 0.57) at 298.2 K and I = 0.05 mol dm(-3) (NEt4ClO4). These data are compared with those for the alkaline earth complexes of 4-{2-[10-(2-morpholinoethyl)-9-anthryl] ethyl} morpholine. In 40 : 60 (v/v) 1,4-dioxan/water, protonation modulates PET to increase the fluorescence of (1) H-4(4+) and ( 2) H-2(2+). (The pK(a) values of (1) H-4(4+) are 9.02, 8.06, 4.32, and 2.96 at 298.2 K and I = 0.05 mol dm(-3) (NEt4ClO4).) The syntheses of (1) and (2) are reported.

Interested yet? Read on for other articles about 88-68-6, you can contact me at any time and look forward to more communication. Formula: C7H8N2O.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem