Related Products of 529-35-1, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 529-35-1, Name is 5,6,7,8-Tetrahydro-1-naphthol, SMILES is OC1=C2CCCCC2=CC=C1, belongs to thiomorpholine compound. In a article, author is Ayers, Sloan, introduce new discover of the category.
Amine over-alkylation side products in the synthesis of BMS-955176
Over-alkylation side products are common in the alkylation of amines by substitution. In the synthesis of the novel HIV Maturation inhibitor BMS-955176, two over-alkylation byproducts were routinely observed at the penultimate synthetic step, in which a thiomorpholine dioxide side chain was added to the core molecule by alkylation of a primary amine. These two byproducts had drastically different HPLC relative retention times, despite both containing only one additional side chain. Adding complexity to the challenge of solving their structures was the proclivity of the two byproducts to interconvert. Positive- and negative-ion HRMS, as well as isolation and 1D and 2D NMR were utilized to determine their structures. These byproducts were additionally problematic in that they led to daughter impurities at the API step. (C) 2018 Elsevier Ltd. All rights reserved.
Related Products of 529-35-1, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 529-35-1.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem