Day: April 1, 2021

Synthetic Route of 64-10-8, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 64-10-8, Name is 1-Phenylurea, SMILES is OC(=N)NC1=CC=CC=C1, belongs to thiomorpholine compound. In a article, author is Mezil, Lynda, introduce new discover of the category.

Tumor Selective Cytotoxic Action of a Thiomorpholin Hydroxamate Inhibitor (TMI-1) in Breast Cancer

Background: Targeted therapies, associated with standard chemotherapies, have improved breast cancer care. However, primary and acquired resistances are frequently observed and the development of new concepts is needed. High-throughput approaches to identify new active and safe molecules with or without an a priori” are currently developed. Also, repositioning already-approved drugs in cancer therapy is of growing interest. The thiomorpholine hydroxamate compound TMI-1 has been previously designed to inhibit metalloproteinase activity for the treatment of rheumatoid arthritis. We present here the repositioning of TMI-1 drug in breast cancer. Methodology/Principal Findings: We tested the effect of TMI-1 on luminal, basal and ERBB2-overexpressing breast tumor cell lines and on MMTV-ERBB2/neu tumor evolution. We measured the effects on i) cell survival, ii) cell cycle, iii) extrinsic and intrinsic apoptotic pathways, iv) association with doxorubicin, docetaxel and lapatinib, v) cancer stem cells compartment. In contrast with conventional cytotoxic drugs, TMI-1 was highly selective for tumor cells and cancer stem cells at submicromolar range. All non-malignant cells tested were resistant even at high concentration. TMI-1 was active on triple negative (TN) and ERBB2-overexpressing breast tumor cell lines, and was also highly efficient on human and murine primary” ERBB2-overexpressing cells. Treatment of transgenic MMTV-ERBB2/neu mice with 100 mg/kg/day TMI-1 alone induced tumor apoptosis, inhibiting mammary gland tumor occurrence and development. No adverse effects were noticed during the treatment. This compound had a strong synergistic effect in association with docetaxel, doxorubicin and lapatinib. We showed that TMI-1 mediates its selective effects by caspase-dependent apoptosis. TMI-1 was efficient in 34/40 tumor cell lines of various origins (ED50: 0.6 mu M to 12.5 mu M). Conclusions/Significance: This is the first demonstration of the tumor selective cytotoxic action of a thiomorpholin hydroxamate compound. TMI-1 is a novel repositionable drug not only for the treatment of adverse prognosis breast cancers but also for other neoplasms.

Synthetic Route of 64-10-8, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 64-10-8.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.115-86-6, Name is Triphenyl phosphate, SMILES is O=P(OC1=CC=CC=C1)(OC2=CC=CC=C2)OC3=CC=CC=C3, belongs to thiomorpholine compound. In a document, author is Sreerama, Rakesh, introduce the new discover, Safety of Triphenyl phosphate.

One-pot synthesis of sulfonyl-1H-1,2,3-triazolyl-thiomorpholine 1,1-dioxide derivatives and evaluation of their biological activity

A one-pot procedure for the synthesis of novel 1,2,3-triazole derivatives (5a-5l) in good yields (63 to 77%) using different sulfonic acids and 4-(prop-2-yn-1-yl)thiomorpholine 1,1-dioxide through the in situ generated sulfonyl azides was developed. The structures of the newly synthesized compounds were confirmed by H-1 NMR, C-13 NMR, mass spectrometry, and elemental analysis. The newly synthesized compounds were screened for in vitro antibacterial activity and free radical scavenging activity in terms of hydrogen donating or radical scavenging ability by the DPPH method. Among all, the compound N-(4-((4-((1,1-dioxidothiomorpholino) methyl)-1H-1,2,3-triazol-1-yl)sulfonyl)phenyl) acetamide (5l) was found to exhibit potent activity as compared to the standard drugs.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 115-86-6. Safety of Triphenyl phosphate.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Category: thiomorpholine, 455-14-1, Name is 4-(Trifluoromethyl)aniline, SMILES is C1=C(C(F)(F)F)C=CC(=C1)N, in an article , author is Walker, Daniel P., once mentioned of 455-14-1.

Preparation of Novel Bridged Bicyclic Thiomorpholines as Potentially Useful Building Blocks in Medicinal Chemistry

Thiomorpholine and thiomorpholine 1,1-dioxide are important building blocks in medicinal chemistry research, and some analogues containing these moieties have entered human clinical trials. Analogues containing bridged bicyclic thiomorpholines have also shown interesting biological profiles. 3-Thia-6-azabicyclo[3.1.1]heptane, 3-thia-8-azabicyclo[3.2.1]octane, and their corresponding 1,1-dioxide counterparts were prepared as novel bicyclic thiomorpholine building blocks. Each heterocycle was synthesized from an inexpensive starting material by straightforward chemistry.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 455-14-1, you can contact me at any time and look forward to more communication. Category: thiomorpholine.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 99-10-5, Name is 3,5-Dihydroxybenzoic acid, molecular formula is C7H6O4, belongs to thiomorpholine compound. In a document, author is Zelenkova, N. F., introduce the new discover, SDS of cas: 99-10-5.

Chromatographic determination of morpholine and products of its microbiological degradation

A combination of thin-layer chromatography (TLC) with high-performance liquid chromatography (HPLC) was shown to be efficient in determining the intermediate products of the utilization of thiomorpholine with ligninolytic basidiomycete fungus Bjerkandera adusta VKM F-3477. The chromatographic mobility of the products of microbiological degradation of thiomorpholine was studied on Sorbfil PTSKh-P-V plates in the systems of chloroform-methanol-25% aqueous ammonia (80: 20: 2) for determining cyclic amines and isopropanol-25% aqueous ammonia (70: 30) for determining thio acids. The optimum conditions were selected for the separation of thiomorpholine and the formed metabolites by ion-exchange chromatography and reversed-phase chromatography.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 99-10-5. SDS of cas: 99-10-5.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Synthetic Route of 938-18-1, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 938-18-1, Name is 2,4,6-Trimethylbenzoyl Chloride, SMILES is O=C(Cl)C1=C(C)C=C(C)C=C1C, belongs to thiomorpholine compound. In a article, author is Aydinli, Serdar Goksin, introduce new discover of the category.

Synthesis, characterization and investigation of antibacterial and antifungal activities of novel 1,3-butadiene compounds

The nitro group-substituted perhalogenobuta-1,3-diene (1) is important synthetic precursor in the synthesis of different heterocycles groups with high biological activity. Firstly, new N,S-substituted-perhalonitro-1,3-butadiene compounds were synthesized by the reactions of various amino or thiol containing nucleophiles with1. The structures of all new compounds have been identified by using spectroscopic techniques (FT-IR,H-1-NMR,C-13-NMR, MS and microanalysis). Secondly, their antimicrobial properties were tested as potential antibacterial and antifungal agents. Antimicrobial activity of synthesized N,S-substituted perhalonitrobutadienes4a-jand5a-dwas evaluated againstEscherichia coliB-906,Staphylococcus aureus209-P, andMycobacterium luteumB-917 bacteria andCandida tenuisVKM Y-70 andAspergillus nigerF-1119 fungi and the compounds4c,4d,5aand5bwith high antifungal action against test-cultureAspergillus nigerat MIC values 0.9-1.9 mu g/cm(3)were identified as the most potent.

Synthetic Route of 938-18-1, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 938-18-1.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Safety of Sodium 3-nitrobenzoate, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 827-95-2, Name is Sodium 3-nitrobenzoate, molecular formula is C7H4NNaO4. In an article, author is Benharref, Ahmed,once mentioned of 827-95-2.

Crystal structure of (1S,2R,4R,9S,11S,12R)-9 alpha-hydroxy-4,8-dimethyl-12-[(thiomorpholin-4-yl)methyl]-3,14-dioxatricyclo[9.3.0.0(2,4)]tetradec-7-en-13-one

The title compound, C19H29NO4S, was synthesised from 9 alpha-hydroxyparthenolide (9 alpha-hydroxy-4,8-dimethyl-12-methylene-3,14-dioxatricyclo[9.3.0.0(2,4)]tetradec-7-en-13-one), which was isolated from the chloroform extract of the aerial parts of the plant Anvillea radiata. The molecule is built up from two fused five-and ten-membered rings, with an additional epoxy ring system and a thiomorpholine group as a substituent. The ten-membered ring adopts an approximate chair-chair conformation, while the thiomorpholine ring displays a chair conformation and the five-membered ring has an envelope conformation, with the C atom closest to the hydroxy group forming the flap. An intramolecular O-H center dot center dot center dot N hydrogen bond closes an S(8) ring. The crystal structure features weak C-H center dot center dot center dot O hydrogen-bonding interactions, which link the molecules into [010] chains.

If you¡¯re interested in learning more about 827-95-2. The above is the message from the blog manager. Safety of Sodium 3-nitrobenzoate.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Reference of 90-15-3, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 90-15-3, Name is 1-Naphthol, SMILES is OC1=C2C=CC=CC2=CC=C1, belongs to thiomorpholine compound. In a article, author is Michalska, Katarzyna, introduce new discover of the category.

Spectroscopic identification of intermediates and final products of the chiral pool synthesis of sutezolid

Sutezolid is a new oxazolidinone derivative currently in clinical trials to determine its safety and efficacy towards highly drug-resistant tuberculosis. The aim of the study was the spectroscopic identification of selected key intermediate products of the chiral pool synthesis of sutezolid: (S1) (4-(2-fluoro-4-nitrophenyl)thiomorpholine), (S2) 4-[2-fluoro-4-(benzyloxycarbonyl)aminophenyl] thiomorpholine, (S4) (R)-[[3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-p-toluenesulfonate, (S5) (R)-[[3-(3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]azide, as well as (S6) sutezolid, the final synthesis product. Spectroscopic identification was carried out based on infrared spectra analysis (FT-IR) and Raman scattering. This part of the analysis was supported by quantum chemical calculations based on the density functional theory (DFT) utilizing the B3LYP hybrid functional and the 6-31G(d,p) basis set to obtain reference standards for intermediates and sutezolid. Additionally, the sutezolid configuration was confirmed by analysing the electronic circular dichroism (ECD) spectra of (S)-and (R)-isomers, combined with the time-dependent DFT calculations to simulate ECD spectra depending on the solvent and type of conformers. (C) 2020 Elsevier B.V. All rights reserved.

Reference of 90-15-3, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 90-15-3 is helpful to your research.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 2471-70-7, Name is 6-Methoxy-2-naphthoic acid, molecular formula is C12H10O3. In an article, author is Vargas-Pineday, Gabriela,once mentioned of 2471-70-7, Name: 6-Methoxy-2-naphthoic acid.

Synthesis and characterization of stannacyclododecane-yl-dithiocarbamates

Thirteen new stannacyclododecane dithiocarbamate complexes have been prepared by reacting 12-chloro-12-n-butyl-1,11-dioxa-4,8-dithia-12-stannacyclododecane (1) and 12-chloro-12-n-butyl-1,4,8,11-tetrathia-12-stannacyclododecane (2) with pyrrolidine-, morpholine-, thiomorpholine-, piperidine-, piperazinebis-, and 3-pyrroline-carbodithioates, respectively, as well as with diethyl-dithiocarbamate. All complexes were characterized by elemental analyses, IR, EI-MS, and NMR (H-1, C-13, and Sn-119) studies. The spectroscopic data suggest the replacement of the chlorides by the corresponding dithiocarbamates with monodentate coordination, leading to six-coordinate tin atoms in all the cases.

Interested yet? Keep reading other articles of 2471-70-7, you can contact me at any time and look forward to more communication. Name: 6-Methoxy-2-naphthoic acid.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 1426129-50-1, Name is (R)-tert-Butyl (1-([1,1′-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate, molecular formula is , belongs to thiomorpholine compound. In a document, author is Liu, Guotao, Recommanded Product: (R)-tert-Butyl (1-([1,1′-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate.

Regulating glutathione-responsiveness of naphthalimide-based fluorescent probes by an oxidation strategy

Two naphthalimide-based fluorescent probes containing a thiomorpholine (Np-NS) or a sulfoxide-morpholine (Np-NSO) component are reported. The morpholine unit of non-fluorescent Np-NS and Np-NSO can transform into sulphone-morpholine and be accompanied by blue fluorescence upon oxidative stress, ascribed to the formation of sulphone-morpholine on probes. This sensing behavior displays that they can selectively respond to glutathione to generate a green emission by a sulfonamide-based detection moiety both in vitro and in living cells. Interestingly, the different oxidation states of a sulphur atom on a thiomorpholine ring can be utilized to regulate responsiveness of these probes towards glutathione. Such an oxidation strategy would provide a possibility for enhancing the response rate.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1426129-50-1, in my other articles. Recommanded Product: (R)-tert-Butyl (1-([1,1′-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 653-37-2, Name is 2,3,4,5,6-Pentafluorobenzaldehyde, molecular formula is C7HF5O. In an article, author is Jarvis, Claire L.,once mentioned of 653-37-2, Recommanded Product: 2,3,4,5,6-Pentafluorobenzaldehyde.

Redox-Neutral alpha-Sulfenylation of Secondary Amines: Ring-Fused N,S-Acetals

Secondary amines react with thiosalicylaldehydes in the presence of catalytic amounts of acetic acid to generate ring-fused N,S-acetals in redox-neutral fashion. A broad range of amines undergo alpha-sulfenylation, including challenging substrates such morpholine, thiomorpholine, and piperazines. Computational studies employing density functional theory indicate that acetic acid reduces the energy barriers of two separate steps, both of which involve proton transfer.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 653-37-2, you can contact me at any time and look forward to more communication. Recommanded Product: 2,3,4,5,6-Pentafluorobenzaldehyde.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem