Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Product Details of 2835-06-5, 2835-06-5, Name is H-DL-Phg-OH, SMILES is O=C(O)C(N)C1=CC=CC=C1, belongs to thiomorpholine compound. In a document, author is Demirci, Serpil, introduce the new discover.
Conventional and Microwave-assisted Total Synthesis, Antioxidant Capacity, Biological Activity, and Molecular Docking Studies of New Hybrid Compounds
Thiomorpholine was converted to the corresponding 1,3,4-oxadiazole (4), arylidenehydrazide (5a-e), and 1,2,4-triazole (7a and, 7b) derivatives via the formation of hydrazide (3). Compounds 4 and 7 were next converted to the corresponding Mannich bases containing piperidin, beta-lactam, fluoroquinolone, piperazine, or morpholine core. Conventional and microwave-assisted methods were used for all syntheses. The effect of acid catalyst on Mannich reactions was also investigated. All the newly synthesized compounds were screened for their antimicrobial, antiglucosidase, antilipase, anti-urease, and antioxidant activities. Most exhibited good-moderate antibacterial and/or antifungal activity. Docking of some of the synthesized compounds into the active sites of lipase, alpha-glucosidase, and urease was carried out in order to predict the binding affinities and noncovalent interactions stabilizing the enzyme-ligand complexes. Docking results complemented well the experimental results on inhibitory effects of compounds. Higher binding affinities were observed for active compounds in contrary to inactive ones.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 2835-06-5. Product Details of 2835-06-5.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem