Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. , SDS of cas: 1965-09-9, 1965-09-9, Name is 4,4-Oxydiphenol, molecular formula is C12H10O3, belongs to thiomorpholine compound. In a document, author is Strotman, Neil A., introduce the new discover.
Development of a Safe and High-Throughput Continuous Manufacturing Approach to 4-(2-Hydroxyethyl)thionnorpholine 1,1-Dioxide
Continuous processing enabled the highly energetic double conjugate addition of ethanolamine to divinylsulfone to prepare 2 kg of 4-(2-hydroxyethyl)thiomorpholine 1,1-dioxide, as an intermediate in the synthesis of HIV Maturation Inhibitor BMS-955176. In situ IR was employed to monitor the steady state of the transformation for increased robustness via appearance of the thiomorpholine dioxide moiety and disappearance of the divinylsulfone. Surprisingly, a series of oligomers formed as intermediates, which converted to product with extended aging or heating, consistent with computational predictions. By running this process in flow, the highly exothermic reaction could be safely executed in an equal volume of water as the only solvent, despite an adiabatic temperature rise of 142 degrees C, leading to a streamlined and efficient process.
Future efforts will undeniably focus on the diversification of the new catalytic transformations. These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. 1965-09-9, you can contact me at any time and look forward to more communication. SDS of cas: 1965-09-9.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem