In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. In homogeneous catalysis, catalysts are in the same phase as the reactants. 611-19-8, Name is 1-Chloro-2-(chloromethyl)benzene, molecular formurla is C7H6Cl2. In a document, author is Krasheninina, Olga A., introducing its new discovery. COA of Formula: C7H6Cl2.
Postsynthetic On-Column 2 ‘ Functionalization of RNA by Convenient Versatile Method
We report a universal straightforward strategy for the chemical synthesis of modified oligoribonucleotides containing functional groups of different structures at the 2 ‘ position of ribose. The on-column synthetic concept is based on the incorporation of two types of commercial nucleotide phosphoramidites containing orthogonal 2 ‘-O-protecting groups, namely 2 ‘-O-thiomorpholine-carbothioate (TC, as permanent) and 2 ‘-O-tert-butyl(dimethyl)silyl (tBDMS, as temporary), to RNA during solid-phase synthesis. Subsequently, the support-bound RNA undergoes selective deprotection and follows postsynthetic 2 ‘ functionalization of the naked hydroxyl group. This convenient method to tailor RNA, utilizing the advantages of solid phase approaches, gives an opportunity to introduce site-specifically a wide range of linkers and functional groups. By this strategy, a series of RNAs containing diverse 2 ‘ functionalities were synthesized and studied with respect to their physicochemical properties.
Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.If you are interested in 611-19-8, you can contact me at any time and look forward to more communication. COA of Formula: C7H6Cl2.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem