Related Products of 607-81-8, Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction. 607-81-8, Name is Diethyl benzylmalonate, SMILES is C1=C(CC(C(OCC)=O)C(OCC)=O)C=CC=C1, molecular formula is C14H18O4, belongs to thiomorpholine compound. In a article, author is Barbachyn, MR, introduce new discover of the category.
Identification of a novel oxazolidinone (U-100480) with potent antimycobacterial activity
During the course of our investigations in the oxazolidinone antibacterial agent area, we have identified a subclass with especially potent in vitro activity against mycobacteria. The salient structural feature of these oxazolidinone analogues, 6 (U-100480), 7 (U-101603), and 8 (U-101244), is their appended thiomorpholine moiety. The rational design, synthesis, and evaluation of the in vitro antimycobacterial activity of these analogues is described. Potent activity against a screening strain of Mycobacterium tuberculosis was demonstrated by 6 and 7 (minimum inhibitory concentrations or MIC’s less than or equal to 0.125 mu g/mL). Oxazolidinones 6 and 8 exhibit MIC(90) values of 0.50 mu g/mL or less against a panel of organisms consisting of five drug-sensitive and five multidrug-resistant strains of M. tuberculosis, with 6 being the most active congener. Potent in vitro activity against other mycobacterial species was also demonstrated by 6. For example, 6 exhibited excellent in vitro activity against multiple clinical isolates of Mycobacterium avium complex (MIC’s = 0.5-4 mu g/mL). Orally administered 6 displays in vivo efficacy against M. tuberculosis and M. avium similar to that of clinical comparators isoniazid and azithromycin, respectively. Consideration of these factors, along with a favorable pharmacokinetic and chronic toxicity profile in rats, suggests that 6 (U-100480) is a promising antimycobacterial agent.
Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. A catalyst, therefore, does not appear in the overall stoichiometry of the reaction it catalyzes.I hope my blog about 607-81-8 is helpful to your research. Related Products of 607-81-8.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem