The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. In an article, author is Han, Bei, once mentioned the application of 53499-40-4, Name is 2-(Benzhydryloxy)-N-methylethanamine hydrochloride, molecular formula is C16H20ClNO, molecular weight is 277.7891, MDL number is MFCD00546051, category is thiomorpholine. Now introduce a scientific discovery about this category, Quality Control of 2-(Benzhydryloxy)-N-methylethanamine hydrochloride.
Design, synthesis and primary activity of thiomorpholine derivatives as DPP-IV inhibitors
Thirteen thiomorpholine-bearing compounds were designed and synthesized as dipeptidyl peptidase IV (DPP-IV) inhibitors, with natural and non-natural L-amino acids as the starting materials. Their structures were characterized by H-1 NMR, C-13 NMR and HR-MS. The target compounds were screened for the DPP-IV inhibition, and the preliminary SAR result was obtained. Particularly, compounds 4c, 4d and 4f with good DPP-IV inhibition in vitro were further evaluated through a mouse oral glucose tolerance test (OGTT). The preliminary result showed the potential value for further studies on those thiomorpholine-bearing compounds as DPP-IV inhibitors. (C) 2011 Hai Hong Huang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
The catalyzed pathway has a lower Ea, but the net change in energy that results from the reaction is not affected by the presence of a catalyst. Interested yet? Read on for other articles about 53499-40-4, you can contact me at any time and look forward to more communication. Quality Control of 2-(Benzhydryloxy)-N-methylethanamine hydrochloride.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem