Day: April 26, 2021

Related Products of 624-31-7, Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction. 624-31-7, Name is 1-Iodo-4-methylbenzene, SMILES is CC1=CC=C(I)C=C1, molecular formula is C7H7I, belongs to thiomorpholine compound. In a article, author is Hill, Timothy A., introduce new discover of the category.

Heterocyclic substituted cantharidin and norcantharidin analogues – synthesis, protein phosphatase (1 and 2A) inhibition, and anti-cancer activity

Norcantharidin (3) is a potent PP1 (IC50 = 9.0 +/- 1.4 mu M) and PP2A (IC50 = 3.0 +/- 0.4 mu M) inhibitor with 3-fold PP2A selectivity and induces growth inhibition (GI(50) similar to 45 mu M) across a range of human cancer cell lines including those of colorectal (HT29, SW480), breast (MCF-7), ovarian (A2780), lung (H460), skin (A431), prostate (DU145), neuroblastoma (BE2-C), and glioblastoma (SJ-G2) origin. Until now limited modifications to the parent compound have been tolerated. Surprisingly, simple heterocyclic half-acid norcantharidin analogues are more active than the original lead compound, with the morphilino-substituted (9) being a more potent (IC50 = 2.8 +/- 0.10 mu M) and selective (4.6-fold) PP2A inhibitor with greater in vitro cytotoxicity (GI(50) similar to 9.6 mu M) relative to norcantharidin. The analogous thiomorpholine-substituted (10) displays increased PP1 inhibition (IC50 = 3.2 +/- 0 mu M) and reduced PP2A inhibition (IC50 = 5.1 +/- 0.41 mu M), to norcantharidin. Synthesis of the analogous cantharidin analogue (19) with incorporation of the amine nitrogen into the heterocycle further increases PP1 (IC50 = 5.9 +/- 2.2 mu M) and PP2A (IC50 = 0.79 +/- 0.1 mu M) inhibition and cell cytotoxicity (GI(50) similar to 3.3 mu M). These analogues represent the most potent cantharidin analogues thus reported. Crown Copyright (c) 2007 Published by Elsevier Ltd. All rights reserved.

Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.Welcome to check out more blogs about 624-31-7, in my other articles. Related Products of 624-31-7.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. In an article, author is Mezil, Lynda, once mentioned the application of 93-11-8, Name is Naphthalene-2-sulfonyl chloride, molecular formula is C10H7ClO2S, molecular weight is 226.68, MDL number is MFCD00004087, category is thiomorpholine. Now introduce a scientific discovery about this category, HPLC of Formula: C10H7ClO2S.

Tumor Selective Cytotoxic Action of a Thiomorpholin Hydroxamate Inhibitor (TMI-1) in Breast Cancer

Background: Targeted therapies, associated with standard chemotherapies, have improved breast cancer care. However, primary and acquired resistances are frequently observed and the development of new concepts is needed. High-throughput approaches to identify new active and safe molecules with or without an a priori” are currently developed. Also, repositioning already-approved drugs in cancer therapy is of growing interest. The thiomorpholine hydroxamate compound TMI-1 has been previously designed to inhibit metalloproteinase activity for the treatment of rheumatoid arthritis. We present here the repositioning of TMI-1 drug in breast cancer. Methodology/Principal Findings: We tested the effect of TMI-1 on luminal, basal and ERBB2-overexpressing breast tumor cell lines and on MMTV-ERBB2/neu tumor evolution. We measured the effects on i) cell survival, ii) cell cycle, iii) extrinsic and intrinsic apoptotic pathways, iv) association with doxorubicin, docetaxel and lapatinib, v) cancer stem cells compartment. In contrast with conventional cytotoxic drugs, TMI-1 was highly selective for tumor cells and cancer stem cells at submicromolar range. All non-malignant cells tested were resistant even at high concentration. TMI-1 was active on triple negative (TN) and ERBB2-overexpressing breast tumor cell lines, and was also highly efficient on human and murine primary” ERBB2-overexpressing cells. Treatment of transgenic MMTV-ERBB2/neu mice with 100 mg/kg/day TMI-1 alone induced tumor apoptosis, inhibiting mammary gland tumor occurrence and development. No adverse effects were noticed during the treatment. This compound had a strong synergistic effect in association with docetaxel, doxorubicin and lapatinib. We showed that TMI-1 mediates its selective effects by caspase-dependent apoptosis. TMI-1 was efficient in 34/40 tumor cell lines of various origins (ED50: 0.6 mu M to 12.5 mu M). Conclusions/Significance: This is the first demonstration of the tumor selective cytotoxic action of a thiomorpholin hydroxamate compound. TMI-1 is a novel repositionable drug not only for the treatment of adverse prognosis breast cancers but also for other neoplasms.

HPLC of Formula: C10H7ClO2S, The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find hit molecules. I hope my blog about 93-11-8 is helpful to your research.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. In an article, author is Peter, A, once mentioned the application of 529-35-1, Name is 5,6,7,8-Tetrahydro-1-naphthol, molecular formula is C10H12O, molecular weight is 148.2017, MDL number is MFCD00001734, category is thiomorpholine. Now introduce a scientific discovery about this category, Product Details of 529-35-1.

Application of a new chiral derivatizing agent to the enantioseparation of secondary amino acids

A new chiral derivatizing, agent, (S)-N-(4-nitrophenoxycarbonyl)phenylalanine methoxyethyl ester, (S)-NIFE, was applied for the high-performance liquid chromatographic separation of enantiomers of 19 unnatural secondary amino acids: proline, pipecolic acid analogues, piperazine-2-carboxylic acid, morpholine-3-carboxylic acid, thiomorpholine-3-carboxylic acid and analogues containing the 1,2,3,4-tetrahydroisoquinoline, 1,2,3,4-tetrahydronorharmane, 1,2,3,4-tetrahydro-2-carboline and 2-benzazepine skeletons. Excellent resolutions were achieved for most of the investigated compounds by using a reversed-phase mobile phase system. The conditions of separation were optimized by variation of the mobile phase composition. (C) 2002 Elsevier Science B.V. All rights reserved.

Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.Welcome to check out more blogs about 529-35-1, in my other articles. Product Details of 529-35-1.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

The main research directions are chemical synthesis, new energy materials, nano-ceramics, nano-hybrid composite materials, preparation and modification of special coatings, and research on the structure and performance of functional materials. 79060-88-1, Name is Sodium tetrakis(3,5-bis(trifluoromethyl)phenyl)borate, molecular formurla is C32H12BF24Na. In a document, author is Jeon, Youngeun, introducing its new discovery. SDS of cas: 79060-88-1.

Controlled Reversible Crystal Transformation of Cu(I) Supramolecular Isomers

Four copper(I) coordination polymers (CPs), {[CuIL]center dot CH3CN]}(n) (1), {[CuIL]center dot CHCl3}(n) (2), {[CuIL]center dot CH2Cl2}(n) (3), and [CuIL](n) (4), were prepared by self-assembly reactions between CuI and (2-pyrazinylcarbonyl)thiomorpholine (L). CPs 1-4 are interconnected by rhomboid Cu-I-2-Cu units. CPs 1 and 4 have one-dimensional loop-chain structures, and 2 and 3 adopt two-dimensional network structures. CPs 1-4 are pseudopolymorphic supramolecular isomers. CPs 2′ and 3′ are prepared by removal of solvate molecules from CPs 2 and 3, which are polymorphic supramolecular isomers with CP 4. Reversible crystal-to-crystal transformations were observed under appropriate conditions such as solvent or heat.

Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.Welcome to check out more blogs about 79060-88-1, in my other articles. SDS of cas: 79060-88-1.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

The main research directions are chemical synthesis, new energy materials, nano-ceramics, nano-hybrid composite materials, preparation and modification of special coatings, and research on the structure and performance of functional materials. 90-11-9, Name is 1-Bromonaphthalene, molecular formurla is C10H7Br. In a document, author is Saikia, Anil K., introducing its new discovery. Name: 1-Bromonaphthalene.

Highly regioselective synthesis of 4-tosylthiomorpholine via intramolecular cyclization of N-tethered thioalkenols

A one-pot, metal-free procedure has been developed for the synthesis of 4-tosylthiomorpholine from N-tethered thioalkenols via bromination, cyclization and subsequent elimination reaction in good yields. The reaction is found to be highly regioselective.

The design and synthesis of related molecules that are more effective, more selective, and less toxic than aspirin are important objectives of biomedical research. I hope my blog about 90-11-9 is helpful to your research. Name: 1-Bromonaphthalene.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. , Safety of 1-Ethynyl-4-fluorobenzene, 766-98-3, Name is 1-Ethynyl-4-fluorobenzene, molecular formula is C8H5F, belongs to thiomorpholine compound. In a document, author is Artico, M, introduce the new discover.

N-[4-(1,1 ‘-biphenyl)methyl]-4-(4-thiomorpholinylmethyl)benzenamines as non-oxazolidinone analogues of antimycobacterial U-100480.

Thiomorpholine analogues of U-100480 with the biphenylmethyl group replacing the acetamidomethyloxazolidinone moiety have been synthesized and tested as antimycobacterial agents together with various related derivatives. Some biphenyl derivatives were endowed with high activity against Mycobacterium tuberculosis and other non-tuberculous mycobacteria. (C) 1998 Elsevier Science Ltd. All rights reserved.

The design and synthesis of related molecules that are more effective, more selective, and less toxic than aspirin are important objectives of biomedical research. I hope my blog about 766-98-3 is helpful to your research. Safety of 1-Ethynyl-4-fluorobenzene.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. In an article, author is Geue, JP, once mentioned the application of 98-68-0, Name is 4-Methoxybenzene-1-sulfonyl chloride, molecular formula is C7H7ClO3S, molecular weight is 206.6467, MDL number is MFCD00007446, category is thiomorpholine. Now introduce a scientific discovery about this category, Formula: C7H7ClO3S.

The formation of fluorescent alkali metal and alkaline earth complexes by 1-(2-{10-[2-piperazinoethyl]-9-anthryl}ethyl)piperazine and alkaline earth complexes by 4-(2-{10-[2-(1,4-thiazinan-4-yl)ethyl]-9-anthryl}ethyl)thiomorpholine in acetonitrile

The formation of fluorescent alkali metal and alkaline earth complexes of 1-(2-{10-[2-piperazinoethyl]9- anthryl} ethyl) piperazine ( 1) and alkaline earth complexes by 4-(2-{10-[2-(1,4-thiazinan-4-yl) ethyl]-9-anthryl} ethyl) thiomorpholine ( 2) in acetonitrile is reported. Both ( 1) and ( 2) have ‘fluorophore – spacer – receptor’ structures in the sequences ‘anthracene – dimethylene – piperazine’ and ‘anthracene – dimethylene – thiomorpholine’, respectively. Complexation by alkali metal ions and alkaline earth ions, Mm+, modulate photoinduced electron transfer ( PET) to increase the fluorescence of ( 1) and complexation of alkaline earth ions similarly increases the fluorescence of ( 2). The two receptors of ( 1) and ( 2) may either complex Mm+ singly to form [ML](m+) or cooperatively to form a ‘sandwich’ complex [ML’](m+) characterized together by complexation constant K-1 and quantum yield phi(1). They may also complex two Mm+ in [M2L](2m+) characterized by K-2 and phi(2). Typical data are exemplified for (1) and Mm+ = Na+ by K-1 = 1.33 x 10(5) dm(3) mol(-1) (phi(1) = 0.02) and K-2 = 4.20 x 10(2) dm(3) mol(-1) (phi(1) = 0.07), for (1) and Mm+ = Ca2+ by K-1 = 3.2 x 10(6) dm(3) mol(-1) (phi(1) = 0.34) and K-2 = 1.32 x 10(4) dm(3) mol(-1) (phi(2) = 0.54), and for (2) and Mm+ = Ca2+ by K-1 = 2.29 x 10(4) dm(3) mol(-1) (phi(1) = 0.20) and K-2 = 8.0 x 10(2) dm(3) mol(-1) (phi(2) = 0.57) at 298.2 K and I = 0.05 mol dm(-3) (NEt4ClO4). These data are compared with those for the alkaline earth complexes of 4-{2-[10-(2-morpholinoethyl)-9-anthryl] ethyl} morpholine. In 40 : 60 (v/v) 1,4-dioxan/water, protonation modulates PET to increase the fluorescence of (1) H-4(4+) and ( 2) H-2(2+). (The pK(a) values of (1) H-4(4+) are 9.02, 8.06, 4.32, and 2.96 at 298.2 K and I = 0.05 mol dm(-3) (NEt4ClO4).) The syntheses of (1) and (2) are reported.

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. A catalyst, therefore, does not appear in the overall stoichiometry of the reaction it catalyzes.I hope my blog about 98-68-0 is helpful to your research. Formula: C7H7ClO3S.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

The main research directions are chemical synthesis, new energy materials, nano-ceramics, nano-hybrid composite materials, preparation and modification of special coatings, and research on the structure and performance of functional materials. 611-19-8, Name is 1-Chloro-2-(chloromethyl)benzene, molecular formurla is C7H6Cl2. In a document, author is Ibis, Cemil, introducing its new discovery. COA of Formula: C7H6Cl2.

New N,S-Substituted Nitrobutadienes from Mono(Arylthio)Substituted Nitrobutadienes

N,S-Substituted nitrobutadienes 3a-g were synthesized from the reaction of the thiosubstituted derivatives 1a-g with thiomorpholine 2. The N,S-substituted nitrobutadienes 5a-g were obtained from the reaction of the thiosubstituted butadienes 1a-g with N-diphenylmethyl piperazine 4. The structure of butadiene 3c was elucidated by single crystal X-ray diffraction.

COA of Formula: C7H6Cl2, The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find hit molecules. I hope my blog about 611-19-8 is helpful to your research.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. In homogeneous catalysis, catalysts are in the same phase as the reactants. 4180-23-8, Name is (E)-1-Methoxy-4-(prop-1-en-1-yl)benzene, molecular formurla is C10H12O. In a document, author is Samzadeh-Kermani, Alireza, introducing its new discovery. Product Details of 4180-23-8.

Copper Catalyzed Synthesis of Thiomorpholine Derivatives: A New Entry of Multicomponent Reaction Between Terminal Alkynes, Isothiocyanates, and Aziridines

Copper acetylide was reacted with isothiocyanate and aziridines to form 1,4-thiomorpholine derivatives. Reaction outcome depends highly on the reaction conditions and the particular solvent employed. Optimum conditions are developed using copper iodide in hexafluoro-2-isopropanol at 60 degrees C. Both the alkyl-substituted and aryl-substituted aziridines and terminal alkynes were studied.

The design and synthesis of related molecules that are more effective, more selective, and less toxic than aspirin are important objectives of biomedical research. I hope my blog about 4180-23-8 is helpful to your research. Product Details of 4180-23-8.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Related Products of 64-10-8, Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction. 64-10-8, Name is 1-Phenylurea, SMILES is OC(=N)NC1=CC=CC=C1, molecular formula is C7H8N2O, belongs to thiomorpholine compound. In a article, author is Mezil, Lynda, introduce new discover of the category.

Tumor Selective Cytotoxic Action of a Thiomorpholin Hydroxamate Inhibitor (TMI-1) in Breast Cancer

Background: Targeted therapies, associated with standard chemotherapies, have improved breast cancer care. However, primary and acquired resistances are frequently observed and the development of new concepts is needed. High-throughput approaches to identify new active and safe molecules with or without an a priori” are currently developed. Also, repositioning already-approved drugs in cancer therapy is of growing interest. The thiomorpholine hydroxamate compound TMI-1 has been previously designed to inhibit metalloproteinase activity for the treatment of rheumatoid arthritis. We present here the repositioning of TMI-1 drug in breast cancer. Methodology/Principal Findings: We tested the effect of TMI-1 on luminal, basal and ERBB2-overexpressing breast tumor cell lines and on MMTV-ERBB2/neu tumor evolution. We measured the effects on i) cell survival, ii) cell cycle, iii) extrinsic and intrinsic apoptotic pathways, iv) association with doxorubicin, docetaxel and lapatinib, v) cancer stem cells compartment. In contrast with conventional cytotoxic drugs, TMI-1 was highly selective for tumor cells and cancer stem cells at submicromolar range. All non-malignant cells tested were resistant even at high concentration. TMI-1 was active on triple negative (TN) and ERBB2-overexpressing breast tumor cell lines, and was also highly efficient on human and murine primary” ERBB2-overexpressing cells. Treatment of transgenic MMTV-ERBB2/neu mice with 100 mg/kg/day TMI-1 alone induced tumor apoptosis, inhibiting mammary gland tumor occurrence and development. No adverse effects were noticed during the treatment. This compound had a strong synergistic effect in association with docetaxel, doxorubicin and lapatinib. We showed that TMI-1 mediates its selective effects by caspase-dependent apoptosis. TMI-1 was efficient in 34/40 tumor cell lines of various origins (ED50: 0.6 mu M to 12.5 mu M). Conclusions/Significance: This is the first demonstration of the tumor selective cytotoxic action of a thiomorpholin hydroxamate compound. TMI-1 is a novel repositionable drug not only for the treatment of adverse prognosis breast cancers but also for other neoplasms.

Future efforts will undeniably focus on the diversification of the new catalytic transformations. These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. 64-10-8, you can contact me at any time and look forward to more communication. Related Products of 64-10-8.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem