Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. , Recommanded Product: 607-81-8, 607-81-8, Name is Diethyl benzylmalonate, molecular formula is C14H18O4, belongs to thiomorpholine compound. In a document, author is Strotman, Neil A., introduce the new discover.
Development of a Safe and High-Throughput Continuous Manufacturing Approach to 4-(2-Hydroxyethyl)thionnorpholine 1,1-Dioxide
Continuous processing enabled the highly energetic double conjugate addition of ethanolamine to divinylsulfone to prepare 2 kg of 4-(2-hydroxyethyl)thiomorpholine 1,1-dioxide, as an intermediate in the synthesis of HIV Maturation Inhibitor BMS-955176. In situ IR was employed to monitor the steady state of the transformation for increased robustness via appearance of the thiomorpholine dioxide moiety and disappearance of the divinylsulfone. Surprisingly, a series of oligomers formed as intermediates, which converted to product with extended aging or heating, consistent with computational predictions. By running this process in flow, the highly exothermic reaction could be safely executed in an equal volume of water as the only solvent, despite an adiabatic temperature rise of 142 degrees C, leading to a streamlined and efficient process.
Recommanded Product: 607-81-8, In conclusion, we affirm that quantitative kinetic descriptions of catalytic behavior continue to serve as an indispensable tool to navigate research efforts.you can also check out more blogs about 607-81-8.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem