Application of 123843-67-4, Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter. 123843-67-4, Name is 4-Bromo-2,6-difluorobenzonitrile, SMILES is N#CC1=C(F)C=C(Br)C=C1F, molecular formula is C7H2BrF2N, belongs to thiomorpholine compound. In an article, author is Lima, LM, introduce new discover of the category.
Synthesis and anti-inflammatory activity of phthalimide derivatives, designed as new thalidomide analogues
This paper describes the synthesis and anti-inflammatory activity of new N-phenyl-phthalimide sulfonamides (3a-e) and the isosters N-phenyl-phthalimide amides (4a-e), designed as hybrids of thalidomide (1) and aryl sulfonamide phosphodiesterase inhibitor (2), In these series, compound 3e (LASSBio 468). having a sulfonyl-thiomorpholine moiety, showed potent inhibitory activity on LPS-induced neutrophil recruitment with ED50 = 2.5 mg kg(-1), which was correlated with its inhibitory effect on TNF-alpha level. (C) 2002 Elsevier Science Ltd. All rights reserved.
Application of 123843-67-4, In conclusion, we affirm that quantitative kinetic descriptions of catalytic behavior continue to serve as an indispensable tool to navigate research efforts.you can also check out more blogs about 123843-67-4.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem