As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. In an article, author is Duarte, CD, once mentioned the application of 177034-57-0, Name is 4-((2-Isopropoxyethoxy)methyl)phenol, molecular formula is C12H18O3, molecular weight is 210.27, MDL number is MFCD07782147, category is thiomorpholine. Now introduce a scientific discovery about this category, HPLC of Formula: C12H18O3.
New optimized piperamide analogues with potent in vivo hypotensive properties
We describe herein the structural optimization of new piperamide analogues, designed from two natural prototypes, piperine 1 and piper-dardine 2, obtained from Piper tuberculatum Jacq. (Piperaceae). Molecular modeling studies using semiempirical AMI method were made in order to establish rational modifications to optimize them by molecular simplification. The targeted compounds (10) and (11) were respectively obtained using benzaldehyde (12) and para-anisaldehyde (13) as starting materials. H-1 NMR spectra showed that the target compounds were diastereoselectively obtained as the (E)-isomer, the same geometry of the natural prototypes. These new synthetic amides presented significant hypotensive effects in cardiovascular essays using in vivo methodologies. Compound 11 (N-[5-(4′-methoxyphenyl)2(E)-pentenoyl]thiomorpholine) showed a potency 10,000 times greater than its prototype 5, evidencing an optimization of the molecular architecture for this class of hypotensive drug candidates. (C) 2004 Elsevier B.V. All rights reserved.
Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.Welcome to check out more blogs about 177034-57-0, in my other articles. HPLC of Formula: C12H18O3.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem