As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. In an article, author is Bahia, Malkeet Singh, once mentioned the application of 103-30-0, Name is (E)-1,2-Diphenylethene, molecular formula is C14H12, molecular weight is 180.2451, MDL number is MFCD00064300, category is thiomorpholine. Now introduce a scientific discovery about this category, Product Details of 103-30-0.
Three Dimensional Molecular Field Analysis of Thiomorpholine Analogs of TACE Inhibitors Using Receptor Based Alignment
Thiomorpholine analogs (TML) have been identified as novel class of potent tumor necrosis factor-alpha converting enzyme (TACE) inhibitors. A computational strategy based on molecular docking studies, followed by MFA analysis has been performed to elucidate the atomic details of the TACE/TML interactions and to identify the most important features impacting TACE inhibitory activity of TMLs. The generated MFA model resulted to be well predictive, and gave r(test)(2) 0.723, conventional r(2) 0.982 and r(cv)(2) 0.811. The 3D-QSAR field contributions and the structural features of the TACE binding site showed a good correlation. These studies will be useful to design new TACE inhibitors with improved potency.
Future efforts will undeniably focus on the diversification of the new catalytic transformations. These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. 103-30-0, you can contact me at any time and look forward to more communication. Product Details of 103-30-0.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem