The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. In an article, author is Yamakuma, Michiko, once mentioned the application of 1075-49-6, Name is 4-Vinylbenzoic acid, molecular formula is C9H8O2, molecular weight is 148.16, MDL number is MFCD00002569, category is thiomorpholine. Now introduce a scientific discovery about this category, Formula: https://www.ambeed.com/products/1075-49-6.html.
A new halenaquinone derivative, 1-hydroxyethylhalenaquinone (1), was isolated from the marine sponge Xestospongia sp. as a proteasome inhibitor together with three known compounds, halenaquinone (2) and 3-ketoadociaquinones A (3) and B (4). 1-Hydroxyethylhalenaquinone (1) was the first halenaquinone derivative containing an alkyl group at the keto-furan C-1 position. Compounds 1 and 2 inhibited the chymotrypsin-like activity of the proteasome with IC50 values of 0.19 and 0.63 mu M, respectively, whereas 3 or 4, each containing a thiomorpholine 1,1-dioxide moiety, scarcely inhibited its activity, even at a concentration of 5 mu M.
The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.If you’re interested in learning more about 1075-49-6. The above is the message from the blog manager. Formula: https://www.ambeed.com/products/1075-49-6.html.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem