Application of 83846-85-9, Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction. 83846-85-9, Name is Phenyl(4-(p-tolylthio)phenyl)methanone, SMILES is O=C(C1=CC=CC=C1)C2=CC=C(SC3=CC=C(C)C=C3)C=C2, molecular formula is C20H16OS, belongs to thiomorpholine compound. In a article, author is Hanif, Muhammad, introduce new discover of the category.
Hydroxypyr(id) ones constitute an emerging platform for the design of drug molecules, owing to their favorable biocompatibility and toxicity profiles. Herein, [Ru-II(eta(6)-p-cymene)] complexes with 3-hydroxy-2-pyridinone functionalized with morpholine and thiomorpholine, as a means often used in medicinal chemistry to alter the physicochemical properties of drug compounds, are reported. The compounds underwent hydrolysis of the Ru-Cl bond and the aqua species were stable for up to 48 h in aqueous solution, as observed by H-1 NMR spectroscopy and ESI-MS. The compounds formed adducts with amino acids and proteins through cleavage of the pyridinone ligand. Binding experiments to the nucleosome core particle by means of X-ray crystallography revealed similar reactivity and exclusive binding to histidine moieties of the histone proteins. Preliminary cyclin-dependent kinase 2 (CDK2)/cyclin A kinase inhibitory studies revealed promising activity similar to that of structurally related organometallic compounds.
Future efforts will undeniably focus on the diversification of the new catalytic transformations. These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. 83846-85-9, you can contact me at any time and look forward to more communication. Application of 83846-85-9.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem