New Advances in Chemical Research, May 2021. The prevalence of solvent effects has motivated developing quantitative kinetic, and theoretical assessments of solvent structures and their interactions with reaction intermediates. In an article, author is Blizzard, Timothy A., once mentioned the application of 126534-31-4, Name is (S)-alpha-(Chloromethyl)-2,4-dichlorobenzyl alcohol, molecular formula is C8H7Cl3O, molecular weight is 225.4996, MDL number is MFCD07776655, category is thiomorpholine. Now introduce a scientific discovery about this category, Formula: https://www.ambeed.com/products/126534-31-4.html.
Thrombin is a serine protease that plays a key role in blood clotting. Pyrrolidine 1 is a potent thrombin inhibitor discovered at Merck several years ago. Seven analogs (2-8) of 1 in which the pyrrolidine core was replaced with various heterocycles were prepared and evaluated for activity against thrombin, clotting factors VIIa, IXa, Xa, and XIIa, and trypsin. The thiomorpholine analog 6 was the most active, essentially matching the thrombin inhibitory activity of 1 with slightly improved selectivity over trypsin. (C) 2014 Elsevier Ltd. All rights reserved.
The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.you can check my other blog about 126534-31-4, you can contact me at any time and look forward to more communication. Formula: https://www.ambeed.com/products/126534-31-4.html.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem