New Advances in Chemical Research, May 2021. We’ll be discussing some of the latest developments in chemical about CAS: 579-75-9. In an article, author is Biava, Mariangela, once mentioned the application of 579-75-9, Name is 2-Methoxybenzoic acid, molecular formula is C8H8O3, molecular weight is 152.15, MDL number is MFCD00002431, category is thiomorpholine. Now introduce a scientific discovery about this category, Formula: https://www.ambeed.com/products/579-75-9.html.
A hit optimization procedure based on isosteric and bioisosteric replacement of decorating groups at both the N1 and the C5 phenyl rings of 1,5-diarylpyrroles led to identification of 4-((1-(4-fluorophenyl)-2-methyl- 5-(4-(methylthio) phenyl)-1H-pyrrol-3-yl) methyl) thiomorpholine that is characterized by a very high activity toward both Mycobacterium tuberculosis 103471 and H37Rv strains (MIC values of 0.125 mu g/mL), and a safe profile in terms of cytotoxicity (CC(50) of > 128 mu g/mL) and protection index (> 1000). Antitubercular activity and protection index of the new compound are comparable to those found for the current antitubercular drugs streptomycin and rifampin. (C) 2010 Elsevier Ltd. All rights reserved.
The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.you can check my other blog about 579-75-9, you can contact me at any time and look forward to more communication. Formula: https://www.ambeed.com/products/579-75-9.html.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem