New research progress on 93-03-8 in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 93-03-8, Name is (3,4-Dimethoxyphenyl)methanol, molecular formurla is C9H12O3. In a document, author is Pulipati, Lokesh, introducing its new discovery. Synthetic Route of 93-03-8.
A series of novel piperidine, piperazine, morpholine and thiomorpholine appended dibenzo[b,d] thiophene-1,2,3-triazoles were designed and synthesized utilizing azide-alkyne click chemistry in the penultimate step. The required azide building block 6a-e was synthesized from commercial dibenzo[b, d] thiophene in good yields following five step reaction sequence. All the new analogues 8a-f, 9a-f, 10a-f, 11a-f & 12a-f were characterized by their NMR and mass spectral analysis. Screening all thirty new compounds for in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv, resulted 8a, 8f and 11e as potent analogues with MIC 0.78 mu g/mL, 0.78 mu g/mL & 1.56 mu g/mL, respectively, and has shown lower cytotoxicity. Interestingly, all six piperazine appended dibenzo[b, d] thiophene-1,2,3-triazoles 11a-f exhibited Mtb inhibition activity with MIC 1.56-12.5 mu g/mL. To some extent, the data observed here indicated Mycobacterium tuberculosis inhibition among the appendages is in the order, piperazine > thiomorpholine > morpholine. (C) 2016 Elsevier Ltd. All rights reserved.
The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.you can check my other blog about 93-03-8, you can contact me at any time and look forward to more communication. Synthetic Route of 93-03-8.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem