Interesting scientific research on 2-Amino-5-methylphenol

The design and synthesis of related molecules that are more effective, more selective, and less toxic than aspirin are important objectives of biomedical research. You can also check out more blogs about 2835-98-5. Application In Synthesis of 2-Amino-5-methylphenol.

Application In Synthesis of 2-Amino-5-methylphenol, New discoveries in chemical research and development in 2021.The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 2835-98-5, Name is 2-Amino-5-methylphenol, SMILES is OC1=CC(C)=CC=C1N, molecular formula is C7H9NO, belongs to thiomorpholine compound. In an article, author is Diao, Peng-Cheng, introduce new discover of the category.

Based on our previous screening hit compound 1, a series of novel indole-pyrimidine hybrids possessing morpholine or thiomorpholine moiety were synthesized via an efficient one-pot multistep synthetic method. The antiproliferative activities of the synthesized compounds were evaluated in vitro against four cancer cell lines including HeLa, MDA-MB-231, MCF-7, and HCT116. The results revealed that most compounds possessed moderate to excellent potency. The IC50 values of the most promising compound 15 are 0.29, 4.04, and 9.48 mu M against MCF-7, HeLa, and HCI116 cell lines, respectively, which are 48.0, 4.9, and 1.8 folds more active than the lead compound 1. Moreover, fluorescence-activated cell sorting analysis revealed that compound 14 showing the highest activity against HeLa (IC50 = 2.51 mu M) displayed a significant effect on G(2)/M cell-cycle arrest in a concentration-dependent manner in HeLa cell line. In addition, representative nine active hybrids were evaluated for tubulin polymerization inhibitory activities, and compound 15 exhibited the most potent anti-tubulin activity showing 42% inhibition at 10 mu M. These preliminary results encourage a further investigation on indole-pyrimidine hybrids for the development of potent anticancer agents that inhibit tubulin polymerization. (C) 2017 Elsevier Masson SAS. All rights reserved.

The design and synthesis of related molecules that are more effective, more selective, and less toxic than aspirin are important objectives of biomedical research. You can also check out more blogs about 2835-98-5. Application In Synthesis of 2-Amino-5-methylphenol.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem