New Advances in Chemical Research, May 2021. We’ll be discussing some of the latest developments in chemical about CAS: 13680-35-8. In an article, author is Zhang, JY, once mentioned the application of 13680-35-8, Name is 4,4-Methylenebis(2,6-diethylaniline), molecular formula is C21H30N2, molecular weight is 310.4763, MDL number is MFCD00071552, category is thiomorpholine. Now introduce a scientific discovery about this category, Category: thiomorpholine.
Human peripheral blood polymorphonuclear leukocytes were preincubated with lanthionine, S-(2-aminoethyl)-L-cysteine, and some of their derivatives found in normal human urine and bovine brain, Among these compounds, lanthionine ketimine and to a lesser extent S-(2-aminoethyl)-L-cysteine ketimine enhanced the N-formyl-methionyl-leucyl-phenylalanine-induced superoxide generation. These ketimines induced tyrosyl phosphorylation of 45 kDa protein of cells. The tyrosyl phosphorylation was markedly increased with time, and the phosphorylation process was dependent on the concentration of both ketimines. However, lanthionine, 1,4-thiomorpholine-3,5-dicarboxylic acid, S-(2- aminoethyl)-L-cysteine and 1,4-thiomorpholine-3-carboxylic acid were without effect both on superoxide generation and on tyrosyl phosphorylation of 45 kDa protein, Lanthionine ketimine and S-(2-aminoethyl)-L-cysteine ketimine also enhanced superoxide generation induced by opsonized zymosan but not the one induced by arachidonic acid and phorbol 12-myristate 13-acetate. Ketimine-primed superoxide generation and tyrosyl phoshorylation of 45 kDa protein were inhibited by genistein, an inhibitor of protein tyrosine kinase, but not by 1-(5-isoquinoline sulfonyl)-2-methylpiperazine, an inhibitor of protein kinase C.
The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.you can check my other blog about 13680-35-8, you can contact me at any time and look forward to more communication. Category: thiomorpholine.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem