Application In Synthesis of 4-Bromo-2-fluoronitrobenzene, New discoveries in chemical research and development in 2021.The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 321-23-3, Name is 4-Bromo-2-fluoronitrobenzene, SMILES is BrC1=CC(=C(C=C1)[N+](=O)[O-])F, molecular formula is C6H3BrFNO2, belongs to thiomorpholine compound. In an article, author is Ghorab, M. M., introduce new discover of the category.
Interaction of dapson [bis(4-aminophenyl)sulfone] 1 with [bis-(methylsulfonyl) methylidine]malononitrile 2 yielded the corresponding dicyano derivative 3, which was reacted with acetic anhydride, succinic anhydride, 4-chlorobenzaldehyde, phenyl isothiocyanate to give the corresponding acetamide 4, succinamic acid 5, pyrrolidine 6, Shiff base 7 and thiourea 8, respectively. Treatment of 3 with chloroacetyl chloride afforded the aminoacetyl chloride derivative 9. Further, the interaction of compound 9 with thioglycolic acid, malononitrile, ethyl glycinate hydrochloride, and/or potassium thiocyanate furnished compounds 10-15, respectively. The structural characterization of the prepared compounds was based on microanalytical and spectroscopic analyses. Some of the prepared compounds were tested for their antimicrobial and antitumor activities. Compounds 9 and 12 showed promising antitumor activity compared with Doxorubicin as positive control.
Keep reading other articles of 321-23-3. Don’t worry, you don’t need a PhD in chemistry to understand the explanations! Application In Synthesis of 4-Bromo-2-fluoronitrobenzene.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem