New discoveries in chemical research and development in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In an article, author is Graton, J, once mentioned the application of 321-23-3, Name is 4-Bromo-2-fluoronitrobenzene, molecular formula is C6H3BrFNO2, molecular weight is 220, MDL number is MFCD01930221, category is thiomorpholine. Now introduce a scientific discovery about this category, Electric Literature of 321-23-3.
Using 4-fluorophenol as a reference hydrogen-bond donor, equilibrium constants K for the formation of 1 : 1 hydrogen-bonded complexes have been obtained by FTIR spectrometry for 33 secondary amines in CCl4 and/or C2Cl4 at 298 K. A spectroscopic scale of hydrogen-bond basicity is constructed from the IR frequency shift Av(OH) of methanol hydrogen-bonded to secondary amines. The comparison of the pK(HB) (log K), Deltav(OH), and pK(a) scales points to the sensitivity of pK(HB) to steric effects, and of Deltav(OH) to the p character of the nitrogen lone pair. The pKHB scale of secondary amines extends from 2.59 for pyrrolidine to -0.45 for (Me3Si)(2)NH. The main effects explaining the pK(HB) variations are (i) the opposite polarizability and steric effects in alkylamines, (ii) field-inductive effects (e.g N drop CCH2NHMe), (iii) intramolecular hydrogen bonding, e.g. in (MeOCH2CH2)(2)NH, and (iv) the ring size giving the order: pyrrolidine = azetidine > piperidine > 2-methylaziridine > azepane. IR spectra show the attachment of 4-fluorophenol to the nitrile nitrogen of N drop CCH2NHMe and N drop CCH2CH2NHMe, to the oxygen of morpholine and (MeOCH2CH2)(2)NH, and to the sulfur of thiomorpholine and thiazolidine, in addition to attachment to the amino nitrogen. The correlation of pK(HB) with the minimum electrostatic potential on the nitrogen lone pair is used for unravelling the basicity of each nitrogen of 1-methyl-1,4-diazepane.
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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem