Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process., Safety of Triphenyl phosphate, 115-86-6, Name is Triphenyl phosphate, molecular formula is C18H15O4P, belongs to thiomorpholine compound. In a document, author is Soliman, Beatrice, introduce the new discover.
Recent studies on histamine receptor (HR) subtypes identified imidazolyl butyl cyanoguanidines, like UR-PI376, as highly potent agonists at the human histamine H-4 receptor (hH(4)R). While imidazole-containing compounds display drawbacks in pharmacokinetics, we studied the possibility of replacing the heteroaromatic cycle by nonaromatic six-membered heterocycles (piperidine, morpholine, thiomorpholine, and N-methylpiperazine) as potential bioisosteres. Beyond that, this approach should give more information about the indispensability of the aromatic ring as a basic head group. Besides these changes, a variation of the spacer length (C-3-C-5) connecting the heterocycle and the cyanoguanidine moiety has been made to possibly trigger the selectivity towards the respective HRs. Investigations in radioligand-binding assays exhibited only very weak activity at the hH(1)R and hH(3)R, while nearly all compounds were inactive at the hH(2)R and hH(4)R. In the case of piperidine-containing compounds, moderate affinities at the hH(3)R over the single-digit micromolar range were detected.
I am very proud of our efforts over the past few months and hope to 115-86-6 help many people in the next few years. Safety of Triphenyl phosphate.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem