HPLC of Formula: https://www.ambeed.com/products/94-09-7.html, New discoveries in chemical research and development in 2021.The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 94-09-7, Name is Ethyl 4-aminobenzoate, SMILES is O=C(OCC)C1=CC=C(N)C=C1, molecular formula is C9H11NO2, belongs to thiomorpholine compound. In an article, author is Vazquez-Valadez, Victor H., introduce new discover of the category.
The inhibition capacity of the angiotensin converting enzyme (ACE) was determined by 5 different methylthiomorpholine compounds: (4-tert-butyl-2-(thiomorpholin-4-ylmethyl)phenol (LQM318), 4-tert-butyl-2,6-bis(thiomorpholin-4-ylmethyl)phenol (LQM319), 3,5-bis(thiomorpholin-4-ylmethyl) pyrogallol (LQM322), 4-methoxy-2 -thiomorpholin-4-ylmethyl-1-phenol (LQM328) and 3 ,6-bis(thiomorpholin-4- ylmethyl)benzene-1,2-diol (LQM329), using Captopril as a reference. This last drug is used as an antihypertensive agent and known for its biological effect over ACE. The study was done using the capillary electrophoresis technique, with an in-line reaction using hippuryl-histidyl-leucine (HHL) as substrate to produce hippuric acid (HA). HA was detected at 254 nm, which is the detection wavelength to get the quantification of this compound. That was performed under the experimental conditions reported for such interaction. From this, the electrophoretic mobility of hippuric acid was computed in order to deduce the effective migration time and the recovered quantity, to prove and quantify the in-line activity of the enzyme.
I am very proud of our efforts over the past few months and hope to 94-09-7 help many people in the next few years. HPLC of Formula: https://www.ambeed.com/products/94-09-7.html.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem