Our Top Choice Compound: 102-06-7

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New Advances in Chemical Research, May 2021. The prevalence of solvent effects has motivated developing quantitative kinetic, and theoretical assessments of solvent structures and their interactions with reaction intermediates. In an article, author is Hill, Timothy A., once mentioned the application of 102-06-7, Name is 1,3-Diphenylguanidine, molecular formula is C13H13N3, molecular weight is 211.2624, MDL number is MFCD00001758, category is thiomorpholine. Now introduce a scientific discovery about this category, Quality Control of 1,3-Diphenylguanidine.

Norcantharidin (3) is a potent PP1 (IC50 = 9.0 +/- 1.4 mu M) and PP2A (IC50 = 3.0 +/- 0.4 mu M) inhibitor with 3-fold PP2A selectivity and induces growth inhibition (GI(50) similar to 45 mu M) across a range of human cancer cell lines including those of colorectal (HT29, SW480), breast (MCF-7), ovarian (A2780), lung (H460), skin (A431), prostate (DU145), neuroblastoma (BE2-C), and glioblastoma (SJ-G2) origin. Until now limited modifications to the parent compound have been tolerated. Surprisingly, simple heterocyclic half-acid norcantharidin analogues are more active than the original lead compound, with the morphilino-substituted (9) being a more potent (IC50 = 2.8 +/- 0.10 mu M) and selective (4.6-fold) PP2A inhibitor with greater in vitro cytotoxicity (GI(50) similar to 9.6 mu M) relative to norcantharidin. The analogous thiomorpholine-substituted (10) displays increased PP1 inhibition (IC50 = 3.2 +/- 0 mu M) and reduced PP2A inhibition (IC50 = 5.1 +/- 0.41 mu M), to norcantharidin. Synthesis of the analogous cantharidin analogue (19) with incorporation of the amine nitrogen into the heterocycle further increases PP1 (IC50 = 5.9 +/- 2.2 mu M) and PP2A (IC50 = 0.79 +/- 0.1 mu M) inhibition and cell cytotoxicity (GI(50) similar to 3.3 mu M). These analogues represent the most potent cantharidin analogues thus reported. Crown Copyright (c) 2007 Published by Elsevier Ltd. All rights reserved.

By the way, if you are interested in learning more fun chemistry with your kids, get your hands into one chemistry set now, and start enjoying the best part of chemistry: experiments about 102-06-7. Quality Control of 1,3-Diphenylguanidine.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem