New Advances in Chemical Research in 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. In an article, author is Michniak, BB, once mentioned the application of 104-21-2, Name is 4-Methoxybenzyl acetate, molecular formula is C10H12O3, molecular weight is 180.2, MDL number is MFCD00038509, category is thiomorpholine. Now introduce a scientific discovery about this category, Application of 104-21-2.
Dermal penetration enhancers were evaluated (14) using diffusion cell techniques, hairless mouse skin and hydrocortisone as the model drug. The following were synthesized: 1-dodecanoylpiperidine (1), 1-dodecanoylpyrrolidine (2), 1-dodecanoyl-2-piperidinone (3), 1-dodecanoyl-2-pyrrolidinone (4), 2-decylcyclohexanone (5), 2-decylcyclopentanone (6), 4-(dodecanoyl)-thiomorpholine (7), N,N-didodecylacetamide (8) and N-dodecyltricyclo [3.3.1.1(3,7)]decane-1-carboxamide (11). N-Acetylcaprolactam (9), 4-acetylmorpholine (10) and N-dodecylpyrrolidinone (13) were purchased. The syntheses of Azone, N-(1-oxododecyl)morpholine (12) and N-dodecyl-2-piperidinone (14) have been reported previously. Enhancers were applied at 0.4 M in propylene glycol (PG) (or as a suspension) to mouse skin. Hydrocortisone (0.03 M in PG) was applied 1 h following enhancer treatment. Controls (no pretreatment) yielded 24 h diffusion cell receptor concentrations (Q(24)) of 9.93 +/- 3.15 mu M and model drug skin retention of 26.1 +/- 5.6 mu g g(-1). Compound 7 yielded a high Q(24) of 208.18 +/- 39.52 mu M. The highest skin retention was observed with 6 of 566.7 +/- 39.7 mu g g(-1). Azone gave values of 218.96 +/- 47.84 mu M for Q(24) and 294.9 +/- 66.7 mu g g(-1) for skin retention. Compounds 13 and 14 gave Q(24) values of 274.44 +/- 50.90 and 220.21 +/- 59.63 mu M and skin retention values of 226.5 +/- 51.8 and 259.0 +/- 62.2 mu g g(-1), respectively. (C) 1998 Elsevier Science B.V.
Application of 104-21-2, In the meantime we’ve collected together some recent articles in this area about 104-21-2. to whet your appetite. Happy reading!
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem