New research progress on 125464-42-8 in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 125464-42-8, Name is 3-Amino-2-(4-chlorophenyl)propane-1-sulfonic acid, molecular formurla is C9H12ClNO3S. In a document, author is Lanoix, J. -P., introducing its new discovery. Application of 125464-42-8.
In the context of increasing drug resistance among Mycobacterium tuberculosis (Mtb) strains, new, potent and well tolerated drugs are urgently needed. Bedaquiline has obtained accelerated approval, but additional novel agents are needed to enable effective combination chemotherapy of extensively drug-resistant tuberculosis (TB). Linezolid, the first and only marketed oxazolidinone antibiotic, has shown certain activity against Mtb. However, serious safety concerns related to long-term administration have limited its utility for TB treatment. Sutezolid (formerly PNU-100480) is a thiomorpholine analogue of linezolid with greater potency in several experimental TB models and the potential for a superior safety profile. This article reviews available preclinical and clinical data regarding the pharmacokinetics, safety and efficacy of sutezolid and presents the case for its further development for the treatment of TB.
Application of 125464-42-8, You can get involved in discussing the latest developments in this exciting area about 125464-42-8.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem