Chemical Research Letters, May 2021. Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media. 489-84-9, Name is Guaiazulene, molecular formurla is C15H18. In a document, author is Soliman, Beatrice, introducing its new discovery. Safety of Guaiazulene.
Recent studies on histamine receptor (HR) subtypes identified imidazolyl butyl cyanoguanidines, like UR-PI376, as highly potent agonists at the human histamine H-4 receptor (hH(4)R). While imidazole-containing compounds display drawbacks in pharmacokinetics, we studied the possibility of replacing the heteroaromatic cycle by nonaromatic six-membered heterocycles (piperidine, morpholine, thiomorpholine, and N-methylpiperazine) as potential bioisosteres. Beyond that, this approach should give more information about the indispensability of the aromatic ring as a basic head group. Besides these changes, a variation of the spacer length (C-3-C-5) connecting the heterocycle and the cyanoguanidine moiety has been made to possibly trigger the selectivity towards the respective HRs. Investigations in radioligand-binding assays exhibited only very weak activity at the hH(1)R and hH(3)R, while nearly all compounds were inactive at the hH(2)R and hH(4)R. In the case of piperidine-containing compounds, moderate affinities at the hH(3)R over the single-digit micromolar range were detected.
The design and synthesis of related molecules that are more effective, more selective, and less toxic than aspirin are important objectives of biomedical research. You can also check out more blogs about 489-84-9. Safety of Guaiazulene.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem