New Advances in Chemical Research, May 2021. We’ll be discussing some of the latest developments in chemical about CAS: 64-10-8. In an article, author is Strotman, Neil A., once mentioned the application of 64-10-8, Name is 1-Phenylurea, molecular formula is C7H8N2O, molecular weight is 136.1512, MDL number is MFCD00007944, category is thiomorpholine. Now introduce a scientific discovery about this category, Recommanded Product: 64-10-8.
Continuous processing enabled the highly energetic double conjugate addition of ethanolamine to divinylsulfone to prepare 2 kg of 4-(2-hydroxyethyl)thiomorpholine 1,1-dioxide, as an intermediate in the synthesis of HIV Maturation Inhibitor BMS-955176. In situ IR was employed to monitor the steady state of the transformation for increased robustness via appearance of the thiomorpholine dioxide moiety and disappearance of the divinylsulfone. Surprisingly, a series of oligomers formed as intermediates, which converted to product with extended aging or heating, consistent with computational predictions. By running this process in flow, the highly exothermic reaction could be safely executed in an equal volume of water as the only solvent, despite an adiabatic temperature rise of 142 degrees C, leading to a streamlined and efficient process.
By the way, if you are interested in learning more fun chemistry with your kids, get your hands into one chemistry set now, and start enjoying the best part of chemistry: experiments about 64-10-8. Recommanded Product: 64-10-8.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem