Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. In an article, author is Fanigliulo, Ameriga, once mentioned the application of 83-56-7, Name is Naphthalene-1,5-diol, molecular formula is C10H8O2, molecular weight is 160.17, MDL number is MFCD00003980, category is thiomorpholine. Now introduce a scientific discovery about this category, Related Products of 83-56-7.
A stability-indicating method for the determination of S-carboxymethyl-L-cysteine and related degradation impurities in Exputex (R) 250 mg/5 mL syrup was developed in anion-exchange liquid chromatography mode. A forced degradation study supported the method development to ensure stability indicating conditions. Aqueous solutions of the active pharmaceutical ingredient and syrup samples at different pH-values were stress-tested in different thermal, light exposure and headspace conditions. One degradation product was detected in thermal stress studies at 60 degrees C and 80 degrees C in the pH range 5.0-7.0 and was identified by mass spectrometry as 5-oxo-thiomorpholine-3-carboxylic acid (lactam of carbocysteine). A second degradation product was only generated in moderately strong oxidizing conditions (0.5% H2O2 aqueous solution) and was identified as S-carboxymethyl-L-cysteine-(R/S)-sulphoxide (carbocysteine sulphoxide). The method was developed on a Zorbax SAX column, in isocratic mode. The mobile phase consisted of 200 mM phosphate solution at pH 4.0 and acetonitrile (50:50 v/v) and UV detection was performed at a wavelength of 205 nm. The method was linear for carbocysteine (R > 0.9982) over a concentration range of 2.5-50 mu g/mL and 0.4-0.6 mg/mL. Linearity for the impurities was shown from the LOQ to 50 mu g/mL. Specificity was verified and accuracy demonstrated for the active ingredient and its degradation products in syrup samples at 3 levels around their respective specification limits. Repeatability, intermediate precision and inter-laboratory reproducibility were assessed on three commercial batches, analyzed in triplicate by two operators at both the transferring and the receiving site and demonstrated a successful method transfer to the manufacturing quality control laboratory. (C) 2015 Elsevier B.V. All rights reserved.
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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem