Extended knowledge of 93-03-8

The design and synthesis of related molecules that are more effective, more selective, and less toxic than aspirin are important objectives of biomedical research. You can also check out more blogs about 93-03-8. Safety of (3,4-Dimethoxyphenyl)methanol.

Application In Synthesis of (3,4-Dimethoxyphenyl)methanol, Chemistry graduates have much scope to use their knowledge in a range of research sectors, including roles within chemical engineering, chemical and related industries, healthcare and more.93-03-8, Name is (3,4-Dimethoxyphenyl)methanol, SMILES is OCC1=CC=C(OC)C(OC)=C1, belongs to thiomorpholine compound. In a article, author is Michalska, Katarzyna, introduce new discover of the category.

Sutezolid is a new oxazolidinone derivative currently in clinical trials to determine its safety and efficacy towards highly drug-resistant tuberculosis. The aim of the study was the spectroscopic identification of selected key intermediate products of the chiral pool synthesis of sutezolid: (S1) (4-(2-fluoro-4-nitrophenyl)thiomorpholine), (S2) 4-[2-fluoro-4-(benzyloxycarbonyl)aminophenyl] thiomorpholine, (S4) (R)-[[3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-p-toluenesulfonate, (S5) (R)-[[3-(3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]azide, as well as (S6) sutezolid, the final synthesis product. Spectroscopic identification was carried out based on infrared spectra analysis (FT-IR) and Raman scattering. This part of the analysis was supported by quantum chemical calculations based on the density functional theory (DFT) utilizing the B3LYP hybrid functional and the 6-31G(d,p) basis set to obtain reference standards for intermediates and sutezolid. Additionally, the sutezolid configuration was confirmed by analysing the electronic circular dichroism (ECD) spectra of (S)-and (R)-isomers, combined with the time-dependent DFT calculations to simulate ECD spectra depending on the solvent and type of conformers. (C) 2020 Elsevier B.V. All rights reserved.

The design and synthesis of related molecules that are more effective, more selective, and less toxic than aspirin are important objectives of biomedical research. You can also check out more blogs about 93-03-8. Safety of (3,4-Dimethoxyphenyl)methanol.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem