In chemical reaction engineering, simulations are useful for investigating and optimizing a particular reaction process or system. In an article, author is Theodosis-Nobelos, Panagiotis, once mentioned the application of 579-75-9, Name is 2-Methoxybenzoic acid, molecular formula is C8H8O3, molecular weight is 152.15, MDL number is MFCD00002431, category is thiomorpholine. Now introduce a scientific discovery about this category, Synthetic Route of 579-75-9.
Objectives: A series of esters and amides, incorporating an antioxidant residue, such as trolox or caffeic acid, and various moieties with different biological activities, were synthesised. Results: The obtained compounds demonstrated considerable anti-inflammatory, radical scavenging and antioxidant action. Thus, they could reduce carrageenan-induced rat paw oedema by 31-60% at 150 mu mol/kg and inhibit rat microsomal membrane lipid peroxidation with IC50 values as low as 1.4 mu M which is much lower than that of trolox. Most of them could also inhibit soybean lipoxygenase. The thiomorpholine derivatives decreased significantly all lipidemic indices of Triton-induced hyper-lipidemia in rats. The most active, the caffeic acid derivative (6), decreases triglycerides, total cholesterol and low density lipoprotein, in the plasma of hyperlipidemic rats, by 70%, 67%, and 73%, respectively, at 150 mu mol/kg (i.p.). Conclusion: The synthesised compounds, designed to exhibit two or more pharmacological actions, may be considered useful in the study of agents addressed to conditions involving inflammation and oxidative stress.
Synthetic Route of 579-75-9, You can get involved in discussing the latest developments in this exciting area about 579-75-9.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem