New research progress on 103-67-3 in 2021. Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment. 103-67-3, Name is N-Methyl-1-phenylmethanamine, molecular formurla is C8H11N. In a document, author is Dal Magro, J, introducing its new discovery. Quality Control of N-Methyl-1-phenylmethanamine.
The kinetics of the nitrosation of 2-hydroxyethylpiperidine have been studied in acidic (0.05-0.30 mol dm(-3) HClO4) aqueous media. The reaction rate is first order with respect to nitrite and amine and independent of acidity and shows an experimental isotope effect of 1.73. The most plausible mechanism involves the fast formation of an alkyl nitrite in the protonated amine (equilibrium constant estimated as 0.014 dm(3) mol(-1)). The loss of a proton from this intermediate is the rate-limiting step, and it is followed by a fast internal nitroso group transfer from the oxygen to the nitrogen atom to give the corresponding N-nitroso compound. A comparison of this nitrosation pathway of secondary amines in acid media with the nitrosation of thiomorpholine and piperidine, and with that of amines by alkyl nitrites in basic media is also discussed.
The design and synthesis of related molecules that are more effective, more selective, and less toxic than aspirin are important objectives of biomedical research. You can also check out more blogs about 103-67-3. Quality Control of N-Methyl-1-phenylmethanamine.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem