Archives for Chemistry Experiments of 2,2-Methylenebis(6-tert-butyl-p-cresol)

I am very proud of our efforts over the past few months and hope to 119-47-1 help many people in the next few years. Electric Literature of 119-47-1.

Chemical engineers work across a number of sectors, but chemistry and chemical engineering roles are found throughout, creation and manufacturing process of chemical products and materials. In an article, author is Barbachyn, MR, once mentioned the application of 119-47-1, Name is 2,2-Methylenebis(6-tert-butyl-p-cresol), molecular formula is C23H32O2, molecular weight is 340.499, MDL number is MFCD00043641, category is thiomorpholine. Now introduce a scientific discovery about this category, Application of 119-47-1.

During the course of our investigations in the oxazolidinone antibacterial agent area, we have identified a subclass with especially potent in vitro activity against mycobacteria. The salient structural feature of these oxazolidinone analogues, 6 (U-100480), 7 (U-101603), and 8 (U-101244), is their appended thiomorpholine moiety. The rational design, synthesis, and evaluation of the in vitro antimycobacterial activity of these analogues is described. Potent activity against a screening strain of Mycobacterium tuberculosis was demonstrated by 6 and 7 (minimum inhibitory concentrations or MIC’s less than or equal to 0.125 mu g/mL). Oxazolidinones 6 and 8 exhibit MIC(90) values of 0.50 mu g/mL or less against a panel of organisms consisting of five drug-sensitive and five multidrug-resistant strains of M. tuberculosis, with 6 being the most active congener. Potent in vitro activity against other mycobacterial species was also demonstrated by 6. For example, 6 exhibited excellent in vitro activity against multiple clinical isolates of Mycobacterium avium complex (MIC’s = 0.5-4 mu g/mL). Orally administered 6 displays in vivo efficacy against M. tuberculosis and M. avium similar to that of clinical comparators isoniazid and azithromycin, respectively. Consideration of these factors, along with a favorable pharmacokinetic and chronic toxicity profile in rats, suggests that 6 (U-100480) is a promising antimycobacterial agent.

I am very proud of our efforts over the past few months and hope to 119-47-1 help many people in the next few years. Electric Literature of 119-47-1.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem