New research progress on 120-07-0 in 2021. Chemical research careers are more diverse than they might first appear, as there are many different reasons to conduct research and many possible environments. 120-07-0, Name is 2,2-(Phenylimino)diethanol, molecular formurla is C10H15NO2. In a document, author is Xu Jian, introducing its new discovery. Related Products of 120-07-0.
A series of artemisone derivatives was prepared from dihydroartemisinin through a seven-step conversion, which included the amination of dihydroartemisinin with thiomorpholine, the oxidation of thiomorpholine (2) with hydrogen peroxide, the alkylation of sulfone (3) with the silyl protected 4-iodobutan-1-ol, the desilylation of artemisone derivative(4), the conversion of alcohol(5) to iodide(6), the amination of iodide (6) with piperazine, and the sulfonylation of compound 7 with a wide arrange of sulfonyl chlorides to the desired artemisone derivatives (8). All the new compounds were identified by NMR spectra, IR and HRMS technology. The anti-tumor activities of artemisone derivatives against human hepatoma SMMC-7721 cell lines were evaluated by 3-(4, 5 -dimethylthiazol-2-yl)-2, 5 -diphenyltetrazolium bromide (MTT) method. It was found that these new artemisone-piperazine-sulfonamide derivatives could inhibit the proliferation of the liver cancer cell by inducing apoptosis, and the lowest IC50 value of the treatment for 72 h was 0. 09 mu mol/mL.
Keep reading other articles of 120-07-0. Don’t worry, you don’t need a PhD in chemistry to understand the explanations! Related Products of 120-07-0.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem