Discovery of Trimethoxy(phenyl)silane

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While the job of a research scientist varies, most chemistry careers in research are based in laboratories, where research is conducted by teams following scientific methods and standards., Application of 2996-92-1, 2996-92-1, Name is Trimethoxy(phenyl)silane, molecular formula is C9H14O3Si, belongs to thiomorpholine compound. In a document, author is Simpson, Denise S., introduce the new discover.

Further synthetic modi. cation of the furan ring of salvinorin A (1), the major active component of Salvia divinorum, has resulted in novel neoclerodane diterpenes with opioid receptor affinity and activity. A computational study has predicted 1 to be a reproductive toxicant in mammals and is suggestive that use of 1 may be associated with adverse effects. We report in this study that piperidine 21 and thiomorpholine 23 have been identified as selective partial agonists at kappa opioid receptors. This indicates that additional structural modi. cations of 1 may provide ligands with good selectivity for opioid receptors but with reduced potential for toxicity.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem