You could be based in a university, combining chemical research with teaching; or in a public-sector research center, helping to ensure national healthcare provision keeps pace with new discoveries. In an article, author is Blizzard, Timothy A., once mentioned the application of 126534-31-4, Name is (S)-alpha-(Chloromethyl)-2,4-dichlorobenzyl alcohol, molecular formula is C8H7Cl3O, molecular weight is 225.4996, MDL number is MFCD07776655, category is thiomorpholine. Now introduce a scientific discovery about this category, Category: thiomorpholine.
Thrombin is a serine protease that plays a key role in blood clotting. Pyrrolidine 1 is a potent thrombin inhibitor discovered at Merck several years ago. Seven analogs (2-8) of 1 in which the pyrrolidine core was replaced with various heterocycles were prepared and evaluated for activity against thrombin, clotting factors VIIa, IXa, Xa, and XIIa, and trypsin. The thiomorpholine analog 6 was the most active, essentially matching the thrombin inhibitory activity of 1 with slightly improved selectivity over trypsin. (C) 2014 Elsevier Ltd. All rights reserved.
The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.you can check my other blog about 126534-31-4, you can contact me at any time and look forward to more communication. Category: thiomorpholine.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem