As a society publisher, everything we do is to support the scientific community – so you can trust us to always act in your best interests, and get your work the international recognition that it deserves., Synthetic Route of 64-10-8, 64-10-8, Name is 1-Phenylurea, molecular formula is C7H8N2O, belongs to thiomorpholine compound. In a document, author is Renaud, T, introduce the new discover.
The electrochemical cyanation of various six-membered N-(2-nitrophenyl) heterocyclic amines, including piperidine, morpholine, thiomorpholine, and N-Boc-protected piperazine derivatives, was investigated. The expected cyanoamines 5 were obtained in good yields and subjected to catalytic hydrogenation to afford the corresponding cyclic amidine N-oxides 6. The reductive cyclization proceeded through the formation of a hydroxylamine, which cyclized onto the cyano moiety. The stereoselectivity of the cyclization reaction was studied for the cases both of trans-5f, in which the substituent was axial and the 4-methyl substituent equatorial, and of cis-5f, in which both the 2-cyano and the substituents were equatorial. The expected tetrahydroquinoxalines 3 were conveniently prepared in a following step by the catalytic hydrogenation of cyclic amidines 6 in the presence of Pearlman’s catalyst at five atmospheres of hydrogen pressure.
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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem